Polymerization of Liposomes(Ⅰ)—— Synthesis of Unsaturated Liposome Monomer

Abstract

Abstract: Polymerizable surfactant,N,N-diethyl-N,N-bis(octadeca-7,9-[or 9,11] dienoyloxyethyl) ammonium bromide has been synthesized by using bleic acid as the starting material. The procedure is as follows: oleic acid is treated by NBS to form allyl bromide. Then the brominated oleic acid is su-bjected to dehydrobromination in the presence of KOH and n-amyl alcohol. Octadecadienoic acid obtained is reacted with PCl₃ to form acyl chloride which is esterified with N,N-diethyl-N,N-bis(hy-droxy ethyl)ammonium bromide at room temperature for 48 h. This new type of polymerizable surfactant may form liposomes under ultrasonic wave irradiation. The average diameter was determined as 600 Å by the light scattering technology

Key words: Liposome, Octadecadienoic acid, Quaternary ammonium salt

TrendMD:

Zhang Liqun, Zhou Hongbing, Zhou Qingzhong, Zhou Qireng, Sun Yanhui . Polymerization of Liposomes(Ⅰ)—— Synthesis of Unsaturated Liposome Monomer[J]. Chem. J. Chinese Universities, 1990, 11(9): 1034.

References

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