Studies on the Synthesis and Anticancer Activity of N-Carbamoyl-N'-(1-Oxyl-2,2,5,5-Tetramethyl-Pyrrolin-3-yl)Urea Compounds

Abstract

Abstract: By the addition of l-oxyl-2, 2, 5, 5-tetramethyl-pyrroline-3-isocyanate (I), synthesized by seven steps,to substituted hydrazides with biological activity, nineteen N-carbamoyl-N'-(1-oxyl-2,2,5,5-tetramethyl-pyrrolin-3-yl) urea compounds were synthesized, The characteristics of electron spin resonance spectra, infrared spectra and mass spectra of some typical compounds of (Ⅲ) were discussed.The preliminary experiment showed that compounds (Ⅲ) possess a inhibiting activity on L7712-leukemia cell and ascitic hepatoma.Especially, the activity of (Ⅲ)_e, as well as of (Ⅲ)_g are more striking.

Key words: Pyrroline nitroxyi radical, Isocyanate, Anticancer activity

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Zhang Ziyi, Wei Lulin, Liu Lisheng, Zheng Rongliang. Studies on the Synthesis and Anticancer Activity of N-Carbamoyl-N'-(1-Oxyl-2,2,5,5-Tetramethyl-Pyrrolin-3-yl)Urea Compounds[J]. Chem. J. Chinese Universities, 1989, 10(12): 1202.

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Studies on the Synthesis and Anticancer Activity of N-Carbamoyl-N'-(1-Oxyl-2,2,5,5-Tetramethyl-Pyrrolin-3-yl)Urea Compounds

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