Synthesis of ZnO/C/SNTs Using Zn-MOF as Template and Their Drug Delivery Ability

doi:10.7503/cjcu20130580

Abstract

Abstract:

Nanocrystallines of metal-organic framework [Zn₆(OH)₃(BTC)₃(H₂O)₃] ·7H₂O(Zn-MOF, BTC=benzene-1,3,5-tricarboxylate) coated with SiO₂ nanotubes(SNTs) were synthesized by a simple one-step ultrasonic route. ZnO/C/SNTs hybrid composites were produced by thermolysis of Zn-MOF/SNTs in N₂ environments, then the drug assemblies of Zn(IBU)₂/C/SNTs were synthesized by the reaction of ibuprofen(HIBU) and ZnO/C/SNTs. The morphology and structure of nanoparticle were characterized by transmission electron microscopy(TEM), high resolution transmission electron microscopy(HRTEM), Fourier transform infrared spectrometry(FTIR) and X-ray diffraction(XRD). The results show that the Zn-MOF/SNTs have clear core-shell structure with rod-like shape, same-sized and well-dispersed. The as-prepared SNTs have better structure stability and the morphologies remain unchangeable after calcination. The results demonstrated that the drug loading was about 752 mg/g, and the drug assemblies had an excellent pH responsive behavior.

Key words: Metal-organic framework, Core-shell structure, Silica nanotube, Sustained release

CLC Number:

O614

TrendMD:

LI Zong-Qun, WANG Ai, GUO Chun-Yan, HU Wen-Na, TAI Yan-Fang. Synthesis of ZnO/C/SNTs Using Zn-MOF as Template and Their Drug Delivery Ability[J]. Chem. J. Chinese Universities, 2013, 34(11): 2470.

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