Synthesis and Antitumor Activities of 3-Arylbenzofunanone Analogues

doi:10.7503/cjcu20130185

Abstract

Abstract:

Starting from methoxyl-substituted benzaldehydes and chloroform, a series of methoxyl-substituted mandelic sodium salts were synthesized in the presence of sodium hydroxide and catalytic amount of tetrabuty-lammonium bromide(TBAB), the corresponding methoxyl-substituted mandelic acids could readily be obtained by acidification. These intermediates on reaction with various substituted phenols in the presence of boron trifluoride etherate via a sequential esterification-alkylation process to give 13 3-arylbenzofunanone analogues in high yields with simple procedures. The inhibitory effects of 11 compounds on cell proliferation were investigated by methylthiazolyldiphenyl-tetrazolium bromide(MTT) method using SW620, A549 and MNNG/HOS cell lines. The results showed that the 3-arylbenzofunanone analogues 4a, 4j and 4a, 4i exhibited some activities against the proliferation of the cell lines.

Key words: 3-Arylbenzofunanone, Methoxyl-substituted mandelic acid, Phenol, Antitumor activity

CLC Number:

O629

TrendMD:

LV Ze-Liang, GAO Yang, LI Jun, HUANG Tong-Kun, HE Shu-Jie, ZOU Yong. Synthesis and Antitumor Activities of 3-Arylbenzofunanone Analogues[J]. Chem. J. Chinese Universities, 2013, 34(11): 2531.

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