Synthesis and Character of Tetra(p-aceto-10-hydroxycamptothecin)phenylporphyrin

doi:10.7503/cjcu20120994

Chem. J. Chinese Universities ›› 2013, Vol. 34 ›› Issue (3): 499.doi: 10.7503/cjcu20120994

• Article: Inorganic Chemistry • Previous Articles Next Articles

Synthesis and Character of Tetra(p-aceto-10-hydroxycamptothecin)phenylporphyrin

GUO Xi-Ming¹, GUO Bin², CHEN Ye-Hong¹

1. School of Life Science and Technology, Harbin Institute of Technology, Harbin 150001, China;
2. Shool of Materials Scince and Engineering, Harbin Institute of Technology, Harbin 150001, China

Received:2012-11-02 Online:2013-03-10 Published:2013-02-18
Contact: guo ximing E-mail:ximing.guo@yahoo.com.cn

Abstract

Abstract:

Tetra(p-aceto-10-hydroxycamptothecin)phenylporphyrin was designed and synthesized through tetrahydroxy-phenylporphyrin and 10-hydroxycamptothecin(HCPT). The structure of tetra(p-aceto-10-hydroxycamptothecin)phenyl porphyrin was confirmed by UV-Vis spectra, IR spectra, ¹H NMR and MALDI-TOF-MS spectra. The mass spectra were measured under different conditions via MALDI-TOF-MS and Agilent LC-MS. Tetra(p-aceto-10-hydroxycamptothecin)phenylporphyrin may play a synergistic effect in threapy of cancer.

Key words: Porphyrin, 10-Hydroxycamptothecin, Tetra-p-chloroacetylphenylporphyrin, Tetra(p-aceto-10-hydroxycamptothecin)phenylporphyrin

CLC Number:

O613
O625.5

TrendMD:

GUO Xi-Ming, GUO Bin, CHEN Ye-Hong. Synthesis and Character of Tetra(p-aceto-10-hydroxycamptothecin)phenylporphyrin[J]. Chem. J. Chinese Universities, 2013, 34(3): 499.

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Synthesis and Character of Tetra(p-aceto-10-hydroxycamptothecin)phenylporphyrin

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