Surface Modification of Layer Double Hydroxide Particles by Poly(ethylene glycol) and Folic Acid

doi:10.7503/cjcu20120877

Abstract

Abstract:

Using (3-aminopropyl)trimethoxy silane(APTMS) as linker agent, the Mg₃Al-NO₃ layer double hydroxides(LDH) particles surface were modified by poly(ethylene glycol)(PEG) with disguise function and folic acid(FA) with targeted function. The obtained surface modified LDH particles(LDH-PEG-FA) were characterized by X-ray diffraction(XRD), transmission electron microscope(TEM), UV-Vis spectrometer, Fourier transform infrared spectrometer(FTIR), laser particle size analyzer and elemental analysis(EA), respectively. The results show that the surface modification of LDH particles can be controlled by the variation of the amount of PEG and FA used in raw materials. Particularly, the modified products exhibit good water re-dispersibility which is mainly attributed to the space steric effect of the modified layers. As the characteristic of disguising and targeting, the LDH-PEG-FA is expected to be used in drug delivery field.

Key words: Layer double hydroxide(LDH), Poly(ethylene glycol), Folic acid(FA), Surface modification, Re-dispersibility

CLC Number:

O648

TrendMD:

XIA Zhi-Yong, DU Na, LIU Jian-Qiang, HOU Wan-Guo. Surface Modification of Layer Double Hydroxide Particles by Poly(ethylene glycol) and Folic Acid[J]. Chem. J. Chinese Universities, 2013, 34(3): 596.

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Surface Modification of Layer Double Hydroxide Particles by Poly(ethylene glycol) and Folic Acid

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