Non-covalent Interaction of Tryptophan with Functional Monomers in Self-assembly Systems

doi:10.7503/cjcu20120492

Abstract

Abstract:

The non-covalent interaction of tryptophan(L-Trp) with adipic dihydrazide(ADH), diacetone acrylamide(DAAM) or acrylic acid(AA) was investigated by fluorescence quenching, three-dimensional fluorescence spectrum in combination with computer simulation, respectively. The quenching mechanism, the strength and types of interaction force between L-Trp and functional monomers were studied. The results showed that the fluorescence of L-Trp was quenched through a static quenching procedure by functional monomer due to the formation of L-Trp-functional monomer complexes. The complexes had high binding constant and exhibited good stability. The non-covalent interaction between L-Trp and functional monomers was dominated by hydrogen bond and electrostatic force. The binding site in L-Trp was supplied largely by carboxyl group rather than heteroaromatic ring. The strength of interaction between L-Trp and functional monomers was in the following order: L-Trp-ADH>L-Trp-DAAM>L-Trp-AA.

Key words: Fluorescence quenching, Three-dimensional fluorescence spectrum, Computer simulation, Tryptophan, Functional monomer, Non-covalent interaction

CLC Number:

O631
O641

TrendMD:

LIN Mei-Na, ZHANG Wei-Ying, LI Xiao, YING Xiao-Guang, CHEN Shuang-Shuang. Non-covalent Interaction of Tryptophan with Functional Monomers in Self-assembly Systems[J]. Chem. J. Chinese Universities, 2013, 34(1): 198.

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Non-covalent Interaction of Tryptophan with Functional Monomers in Self-assembly Systems

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