Preparation and Bioactivities of Electrospun PBS Nanofiber Membrane and Hybrid PBS Nanofiber Membrane of Sustained Release Growth Factors in Platelet

doi:10.7503/cjcu20120006

Chem. J. Chinese Universities ›› 2012, Vol. 33 ›› Issue (12): 2827.doi: 10.7503/cjcu20120006

• Polymer Chemistry • Previous Articles

Preparation and Bioactivities of Electrospun PBS Nanofiber Membrane and Hybrid PBS Nanofiber Membrane of Sustained Release Growth Factors in Platelet

SUN Shu-Fen¹, LI Nan-Nan¹, LIU Min¹, LIU Yi-Cong¹, ZHANG Ying-Chao², ZHOU Yan-Min¹

1. Stomatological Hospital of Jilin University, Changchun 130021, China;
2. State Key Laboratory of Supramolecular Structure and Materials, Jilin University, Changchun 130012, China

Received:2012-01-04 Online:2012-12-10 Published:2012-11-20
Contact: Yan-min ZHOU E-mail:zhouym@jlu.edu.cn

Abstract

Abstract:

Poly(butylene succinate)(PBS) nanofiber membrane and hybrid nanofiber membrane of PBS and platelet-rich plasma(PRP) were prepared by electrospinning. The properties and bioactivities of scaffold materials were evaluated by means of scanning electron microscope(SEM), methyl thiazolyl tetrazolium(MTT), fluorescent staining and laser scanning co-focal microscope, hemolytic properties of materials and enzyme-linked immunosorbent assay(ELISA). The experiment results show that nanofiber membranes can accelerate the proliferation of human osteosarcoma MG63 cells line. Also, in vitro the growth factors in the scaffold material display a sustained release with the scaffold degrading after the initial burst release. In addition, hemolytic rate of scaffold material is 0.1475%(<5%), which meets the demand of hemolytic rate of medial materials.

Key words: Nanofiber membrane, Poly(butylene succinate), Growth factor, Platelet-rich plasma, Sustained release

CLC Number:

O635

TrendMD:

SUN Shu-Fen, LI Nan-Nan, LIU Min, LIU Yi-Cong, ZHANG Ying-Chao, ZHOU Yan-Min. Preparation and Bioactivities of Electrospun PBS Nanofiber Membrane and Hybrid PBS Nanofiber Membrane of Sustained Release Growth Factors in Platelet[J]. Chem. J. Chinese Universities, 2012, 33(12): 2827.

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Preparation and Bioactivities of Electrospun PBS Nanofiber Membrane and Hybrid PBS Nanofiber Membrane of Sustained Release Growth Factors in Platelet

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