高等学校化学学报

高等学校化学学报

• 研究快报 • 上一篇    

共聚物-锌与多肽的相互作用

赵建新1, 乔义涛1, 冯菁1, 罗昭峰2, 袁直1   

    1. 南开大学高分子化学研究所, 功能高分子材料教育部重点实验室, 天津 300071;
    2. 中国科技大学生命科学学院, 合肥 230027
  • 收稿日期:2007-10-08 修回日期:1900-01-01 出版日期:2008-03-10 发布日期:2008-03-10
  • 通讯作者: 袁直

Interaction of Copolymer-Zn with Polypeptide

ZHAO Jian-Xin1, QIAO Yi-Tao1, FENG Jing1, LUO Zhao-Feng2, YUAN Zhi1*   

    1. Key Laboratory of Functional Polymer Materials, Ministry of Education, Institute of Polymer Chemistry, Nankai University, Tianjin 300071, China;
    2. School of Life Sciences, University of Science and Technology of China, Hefei 230027, China
  • Received:2007-10-08 Revised:1900-01-01 Online:2008-03-10 Published:2008-03-10
  • Contact: YUAN Zhi

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被引次数

2

摘要： 合成了一种含有吡啶衍生物功能侧基的共聚物, 考察了共聚物-锌与目标多肽DFLAE(尿毒症多肽毒素片段)的配位作用和疏水作用. 实验结果表明, 共聚物-锌与目标多肽可发生较强的相互作用, 为进一步的作用机理研究和高效能肽吸附剂的设计奠定了基础.

关键词: 多肽, 共聚物, 分子间相互作用

Abstract: A new copolymer(C) was designed and synthesized. Isothermal Titration Calorimetry(ITC) expe-riments showed the strong binding of C-Zn and the predetermined peptide sequences(DFLAE, appear in many peptides sequence which cumulate in serum of uremic patients). The further ITC experiments demonstrate that the binding is the result of the cooperative effect of coordination and hydrophobic interaction, which may provide further understanding on the mechanism of polymer-metal-peptide interaction and a structural basis for designing the adsorbents for the target peptide.

Key words: Polypeptide, Copolymer, Intermolecular interaction

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