高等学校化学学报

高等学校化学学报 ›› 1996, Vol. 17 ›› Issue (1): 69.

• 论文 • 上一篇    下一篇

N1′-甲基靛玉红肟的结构和性质研究

田发安, 龚考才, 李春敏   

  1. 泸州医学院基础部, 泸州 646000
  • 收稿日期:1995-02-28 出版日期:1996-01-24 发布日期:1996-01-24
  • 通讯作者: 田发安,男,59岁,副教授.
  • 作者简介:田发安,男,59岁,副教授.

Studies on the Structure and Properties of N1′-Methyl Indirubin Monooxime

TIAN Fa-An, GONG Kao-Cai, LI Chun-Min   

  1. Departmetn of Basic courses, Luzhou Medical College, Luzhou 646000
  • Received:1995-02-28 Online:1996-01-24 Published:1996-01-24

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摘要： 报道了N1′-甲基靛玉红肟的合成、晶体结构及性质。体外美蓝试验结果表明,它的抗白血病活性明显优于靛玉红,其水溶性和脂溶性都较靛玉红有所增强。用X射线衍射法测得其晶体结构,组成为C17H13N3O2,Mr=291.21,空间群P21/c,晶体学数据:a=1.5226(4),b=0.6524(3),c=1.6562(5)nm;β=103.69(4)°,Z=4.最终偏离因子为0.043.分子近似平面型。

关键词: N1&prime, -甲基靛玉红肟, 抗白血病活性, 分子结构, 晶体结构, 构效关系

Abstract: In this paper the synthesis,crystalline structure and properties of N1′-methyl in-dirubin monooxime(MIM)are reported.The antileukemic activity was determined by themethylene blue method in vitro and proved to be better than that of indirubin clearly. Its wa-ter-solubility and fat-solubility power are better than those of indirubin, Crystalline structure of MIMwas determined by X-ray diffraction method.The crystalline composition C17H13N3O2,Mr=291.21.The crystal is monoclinic,space group P21/c, with a=1.5226(4) nm,b=0. 6524(3)nm,c=1.6562(5) nm:β=103.69(4)°,Z=4.The final deviation factor R=0.043.The molecule is approximately planar.

Key words: N1′-Metliyl indirtibin monooxime, Antileukemia/activity, Molecular structure, Crystalline structure, Structtire-activity relationship

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