高等学校化学学报 ›› 2020, Vol. 41 ›› Issue (10): 2185-2198.doi: 10.7503/cjcu20200537

• 综合评述 • 上一篇    下一篇

CM⁃Phos配体在钯催化交叉偶联反应中的应用

苏秋铭1(), 原安莹1,2, 邝福儿2, 陈志强3, 白呈超3, 辛伟贤3   

  1. 1.香港理工大学应用生物及化学科技学系, 香港
    2.香港中文大学化学系, 香港
    3.广州理文科技有限公司, 广州 510000
  • 收稿日期:2020-08-07 出版日期:2020-10-10 发布日期:2020-10-08
  • 通讯作者: 苏秋铭 E-mail:chau.ming.so@polyu.edu.hk
  • 基金资助:
    国家自然科学基金(21972122);深圳市基础研究计划项目(JCYJ20180306173843318)

Application of CM-Phos Ligand in Palladium-catalyzed Cross-coupling Reactions

SO Chauming1(), YUEN Onying1,2, KWONG Fukyee2, CHEN Chihchiang3, PAI Chengchao3, SUN Raymond Waiyin3   

  1. 1.Department of Applied Biology and Chemical Technology,the Hong Kong Polytechnic University,Hong Kong,China
    2.Department of Chemistry,the Chinese University of Hong Kong,Hong Kong,China
    3.Guangzhou Lee & Man Technology Company Limited,Guangzhou 510000,China
  • Received:2020-08-07 Online:2020-10-10 Published:2020-10-08
  • Contact: SO Chauming E-mail:chau.ming.so@polyu.edu.hk
  • Supported by:
    ? Supported by the National Natural Science Foundation of China(21972122);the Shenzhen Basic Research Program, China(JCYJ20180306173843318)

摘要:

本文综合评述了近年来2-[2-(二环己膦基)苯基]-1-甲基-1H-吲哚(CM-Phos)膦配体及其衍生物在钯催化的交叉偶联反应中的应用, 主要根据不同种类的交叉偶联反应进行系统性分述, 并对该领域的发展前景进行了展望.

关键词: 膦配体, 2-[2-(二环己膦基)苯基]-1-甲基-1H-吲哚, 钯催化, 交叉偶联

Abstract:

Palladium-catalyzed cross-coupling is one of the most effective and widely utilized tools for connecting electrophilic and nucleophilic coupling partners for carbon-carbon or carbon-heteroatom bonds forming reactions. 2-[2-(dicyclohexylphosphino)phenyl]-N-methylindole(CM-Phos) ligand derivatives have proven to be successful catalysts in this context. This review summarizes the recent developments, and applications of different coupling partners in these reactions by using CM-Phos ligand derivatives.

Key words: Phosphine ligand, 2-[2-(Dicyclohexylphosphino)phenyl]-N-methylindole(CM-Phos), Palla- dium-catalyzed, Cross-coupling

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