高等学校化学学报 ›› 2019, Vol. 40 ›› Issue (9): 1932.doi: 10.7503/cjcu20190194

• 物理化学 • 上一篇    下一篇

官能化反蛋白石结构光子晶体的构筑及对肝素的检测

徐娜1,刘众虎1,兰承武1,尹建行1,程凯旋1,孟磊2,*()   

  1. 1. 吉林化工学院材料科学与工程学院
    2. 机电工程学院, 吉林 132022
  • 收稿日期:2019-04-02 出版日期:2019-09-10 发布日期:2019-09-09
  • 通讯作者: 孟磊 E-mail:ml_0512@163.com
  • 基金资助:
    吉林省科技厅基金项目(20180520161JH, 20180520006JH)

Synthesis of Functionalized Inverse Opals Photonic Crystals and the Detection of Heparin

XU Na1,LIU Zhonghu1,LAN Chengwu1,YIN Jianhang1,CHENG Kaixuan1,MENG Lei2,*()   

  1. 1. College of Materials Science and Engineering
    2. College of Mechanical and Electrical Engineering,Jilin Institute of Chemical Technology, Jilin 132022, China
  • Received:2019-04-02 Online:2019-09-10 Published:2019-09-09
  • Contact: MENG Lei E-mail:ml_0512@163.com
  • Supported by:
    ? Supported by the Projects of Jilin Provincial Department of Science and Technology, China(20180520161JH, 20180520006JH)

摘要:

制备了一种具有反蛋白石结构的光子晶体(IOPCs), 通过聚乙烯亚胺(PEI)实现了对该IOPCs的官能化; PEI官能化的IOPCs与肝素之间具有强静电作用, 从而可利用其对肝素进行特异性检测. 研究结果表明, 随着肝素浓度的增加(0~10 -4 mol/L), 官能化IOPCs的布拉格衍射峰最大位移约为40 nm; 肝素浓度的对数与IOPCs的最大衍射波长位移具有良好的线性关系(R 2=0.99905), 检测限为10 -10 mol/L. 该IOPCs具有较好的物理和化学稳定性, 且能重复用于肝素的检测, 具有良好的应用前景.

关键词: 光子晶体, 反蛋白石结构, 肝素检测, 官能化

Abstract:

Heparin is the primary medicine of anticoagulant that can rapidly prevent from blood clotting, which could generate essential hemorrhage or thrombocytopenia for overusing. By functionalizing inverse opals photonic crystals(IOPCs) with polyethylene imine(PEI), the IOPCs manage to specific detect the presence of heparin via strong electrostatic interaction between them. With the concentration of heparin increasing(0—10 -4 mol/L), maximum peak of Bragg diffraction of functionalized IOPCs shifts about 40 nm. There’s fine Linear relation(R 2=0.99905) between logarithm of concentration of heparin and wave shifts of IOPCs, and the limit of detection is 10 -10 mol/L. The IOPCs obtained perform a well physical and chemical stability, which can be repeatedly used in detection of heparin with prospective practical application.

Key words: Photonic crystal, Inverse opals structure, Heparin detection, Function

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