高等学校化学学报 ›› 2016, Vol. 37 ›› Issue (1): 19-25.doi: 10.7503/cjcu20120521

• 分析化学 • 上一篇    下一篇

手性金属-有机骨架材料{[Co(L-trp)(bpe)(H2O)]·H2O·NO3}n用于高效液相色谱的拆分性能

农蕊瑜1, 孔娇1, 章俊辉2, 陈玲1, 汤波1, 谢生明1, 袁黎明1()   

  1. 1. 云南师范大学化学化工学院, 昆明 650500
    2. 华东师范大学化学系, 上海 200241
  • 收稿日期:2015-07-06 出版日期:2016-01-10 发布日期:2015-12-20
  • 基金资助:
    国家自然科学基金(批准号: 21275126, 21365025)资助

Chiral Metal-organic Framework{[Co(L-trp)(bpe)(H2O)]·H2O·NO3}n Used for High Performance Liquid Chromatographic Separation

NONG Ruiyu1, KONG Jiao1, ZHANG Junhui2, CHEN Ling1, TANG Bo1, XIE Shengming1, YUAN Liming1,*()   

  1. 1. Faculty of Chemisty and Chemical Engineering, Yunnan Normal University, Kunming 650500, China
    2. Department of Chemistry, East China Normal University, Shanghai 200241, China
  • Received:2015-07-06 Online:2016-01-10 Published:2015-12-20
  • Contact: YUAN Liming E-mail:yuan_limingpd@126.com
  • Supported by:
    † Supported by the National Natural Science Foundation of China(Nos.21275126, 21365025)

摘要:

L-色氨酸(L-trp)和1,2-二(4-吡啶基)乙烯(bpe)为配体与钴离子反应, 通过水热法合成了一种具有二维手性层面结构的手性金属-有机骨架(MOFs)材料{[Co(L-trp)(bpe)(H2O)]·H2O·NO3}n; 利用X射线粉末衍射(XRD)分析和扫描电子显微镜(SEM)对材料的结构和形貌进行了表征. 将该MOFs材料用作固定相, 制备了液相色谱手性柱, 在正己烷/异丙醇的流动相体系下, 考察了该手性柱对一系列手性化合物的拆分性能. 实验结果表明, 该手性柱对3种苯系物的位置异构体和11种外消旋化合物表现出较好的拆分性能. 在正相色谱条件下, 该手性柱表现出良好的重现性和稳定性.

关键词: 金属-有机骨架材料, 高效液相色谱, 手性拆分

Abstract:

A homochiral MOF {[Co(L-trp)(bpe)(H2O)]·H2O·NO3}n[L-trp=L-tryptophan, bpe=1,2-bis(4-pyridyl)ethylene] with 2D chiral layers was synthesized and used as a new chiral stationary phase for high-performance liquid chromatographic enantioseparation in this study. The chiral MOFs was characterized by powder X-ray diffraction(XRD) and scanning electron microscope(SEM). The experimental results showed that 3 isomers and 11 recemates were separated on {[Co(L-trp)(bpe)(H2O)]·H2O·NO3}n packed column. The chiral column also exhibited good reproducibility and stability.

Key words: Metal-organic framework, High-performance liquid chromatography, Chiral enantioseparation

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