高等学校化学学报

高等学校化学学报

• 研究论文 • 上一篇    下一篇

红树植物海杧果内生真菌Penicillium sp.中的抗菌活性成分

韩壮1,2, 梅文莉2, 崔海滨1,2, 曾艳波2, 林海鹏2, 洪葵2, 戴好富2   

    1. 汕头大学海洋生物研究所, 汕头 515063;
    2. 中国热带农业科学院热带生物技术研究所, 海口 571101
  • 收稿日期:2007-08-20 修回日期:1900-01-01 出版日期:2008-04-10 发布日期:2008-04-10
  • 通讯作者: 戴好富

Antibacterial Constituents from the Endophytic Fungus Penicillium sp. of Mangrove Plant Cerbera manghas

HAN Zhuang1,2, MEI Wen-Li2, CUI Hai-Bin1,2, ZENG Yan-Bo2, LIN Hai-Peng2, HONG Kui2, DAI Hao-Fu2*   

    1. Institute of Marine Biology, Shantou University, Shantou 515063, China;
    2. Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China
  • Received:2007-08-20 Revised:1900-01-01 Online:2008-04-10 Published:2008-04-10
  • Contact: DAI Hao-Fu

PDF (PC)

摘要： 对红树植物海杧果内生真菌Penicillium sp.发酵液的乙酸乙酯提取物进行了柱层析分离, 得到3个化合物, 经MS, NMR, 1H-1H COSY, HMQC和HMBC等鉴定, 分别为4-(3-hydroxybutan-2-yl)-3,6-dimethylbenzene-1,2-diol(1), 4-(3-hydroxybutan-2-yl)-3-methyl-6-acetylbenzene-1,2-diol(2)和3,4,5-trimethyl-1,2-benzenediol(3). 其中化合物1和2为新化合物, 化合物3为新的天然产物. 抗菌活性测试结果表明, 化合物1和3均具有抗耐甲氧西林金黄色葡萄球菌的活性, 化合物2则未显示此活性.

关键词: 红树林植物, 内生真菌, Penicillium sp., 抗菌活性, 化学成分

Abstract: To study the anti-bacterial constituents from endophytic fungus 093701 of mangrove plant Cerbera manghas, three compounds were isolated by column chromatography from the broth of endophytic fungus Penicillium sp. of Mangrove plant Cerbera manghas, and their structures were elucidated as 4-(3-hydroxybutan-2-yl)-3,6-dimethylbenzene-1,2-diol(1), 4-(3-hydroxybutan-2-yl)-3-acetyl-6-methylbenzene-1,2-diol(2), 3,4,5-trimethyl-1,2-benzenediol(3) by MS, NMR, 1H-1H COSY, HMQC, HMBC etc.. Among them, compounds 1 and 2 were new compounds, compound 3 was a new natural product. Bioassay results showed that compounds 1 and 3 possessed inhibitory effects on MRSA, while compound 2 had no anti-MRSA activity.

Key words: Mangrove plant, Endophytic fungus, Penicillium sp., Antibacterial, Chemical constituent

中图分类号: 

TrendMD: