高等学校化学学报

高等学校化学学报 ›› 2013, Vol. 34 ›› Issue (8): 1863.doi: 10.7503/cjcu20121112

• 有机化学 • 上一篇    下一篇

SiC管中微波辅助芳烃钌(Ⅱ)化合物[(η6-C6H6)Ru(H2iiP)Cl]Cl的合成

吴琼1, 梅文杰1,2, 吴韦黎1, 陈燕华1, 曾玲莉1, 郑文杰2   

  1. 1. 广东药学院药科学院, 广州 510006;
    2. 暨南大学化学系, 广州 510632
  • 收稿日期:2012-12-10 出版日期:2013-08-10 发布日期:2013-07-19
  • 通讯作者: 梅文杰,男,博士,教授,主要从事药物化学和生物无机化学研究.E-mail:wenjiemei@126.com;郑文杰,男,博士,教授,博士生导师,主要从事生物无机化学研究.E-mail:tzhwj@jnu.edu.cn E-mail:wenjiemei@126.com;tzhwj@jnu.edu.cn
  • 基金资助:

    国家自然科学基金(批准号: 20771044, 21071062); 广州市科技计划项目(批准号: 2013J4100072)和广东药学院大学生课外科技立项资助.

Microwave-assisted Synthesis of Arene Ru(Ⅱ) Complex [(η6-C6H6)Ru(H2iiP)Cl]Cl in SiC Vessel

WU Qiong1, MEI Wen-Jie1,2, WU Wei-Li1, CHEN Yan-Hua1, ZENG Ling-Li1, ZHENG Wen-Jie2   

  1. 1. School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China;
    2. Department of Chemistry, Jinan University, Guangzhou 510632, China
  • Received:2012-12-10 Online:2013-08-10 Published:2013-07-19

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摘要：

使用SiC管为反应容器, 在微波辐射条件下以[(η6-C6H6)RuCl2]2为原料与2-(吲哚基)咪唑[4,5-f]-[1,10]菲啰啉(H2iiP)反应, 制得芳烃钌(Ⅱ)化合物Cl[(η6-C6H6)Ru(H2iiP)Cl]Cl(1), 并对其进行了表征. 采用正交实验法确定反应的最佳合成条件为: 投料比n([(η6-C6H6)RuCl2]2): n(H2iiP)=1: 2.2, 反应温度90℃, 微波辐射时间30 min. 该反应的平均产率达到96.0%, 反应产率的相对标准偏差(RSD)为1.28%, 说明微波辐射条件下, 在SiC管中能够高产率地制备芳烃钌化合物, 并且反应具有良好的重现性. 进一步采用MTT方法研究发现, 芳烃钌(Ⅱ)化合物1能够选择性抑制MCF-7乳腺癌的生长.

关键词: 2-(吲哚基)咪唑[4,5-f][1,10]菲啰啉, 芳烃钌(Ⅱ)化合物, SiC管, 微波辅助合成, 抗肿瘤

Abstract:

Arene Ru(Ⅱ) complex [(η6-C6H6)Ru(H2iiP)Cl]Cl(1) was synthesized using [(η6-C6H6)·5RuCl2]2 and 2-indole-3-imidazole[4,5-f][1,10] phenanthroline(H2iiP) as raw material under microwave irradiation. The target compound was characterized by means of elemental analysis, ESI-MS, IR and NMR. The best craft condition determined by orthogonal test is that reactant molar ratio of 1.0: 2.2, the reaction tempe-rature of 90℃ and the microwave irradiation time of 30 min. Then the average yield of 96.0% and RSD of 1.28% confirmed that microwave-assisted synthesis of arene Ru(Ⅱ) complex in SiC vessel gives a good stability and reiteration. The antitumor activity of arene Ru(Ⅱ) complex 1 was determined by MTT assay and the results showed that complex 1 could selectively inhibit the growth of MCF-7, indicating its potential utility in chemotherapy.

Key words: 2-Indole-3-imidazole[4,5-f][1,10]phenanthroline(H2iiP), Arene Ru(Ⅱ) complex, SiC vessel, Microwave-assisted synthesis, Antitumor

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