高等学校化学学报 ›› 2011, Vol. 32 ›› Issue (9): 1970.

• 综合评述 • 上一篇    下一篇

三唑类超分子化学与药物研究新进展

常娟娟,王艳,张慧珍,周成合,耿蓉霞,吉庆刚   

  1. 西南大学化学化工学院, 重庆 400715
  • 收稿日期:2011-04-06 修回日期:2011-06-24 出版日期:2011-09-10 发布日期:2011-08-11
  • 通讯作者: 周成合 E-mail:zhouch@swu.edu.cn
  • 基金资助:

    中央高校基本科研业务费专项资金(批准号:   XDJK2009C092)、 国家自然科学基金(批准号:  21172181)和西南大学基金(批准号:  SWUB2006018, XSGX0602)资助.

Recent Advances in Researches of Triazole-based Supramolecular Chemistry and Medicinal Drugs

CHANG Juan-Juan, WANG Yan, ZHANG Hui-Zhen, ZHOU Cheng-He*, GENG Rong-Xia, JI Qing-Gang   

  1. School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, China
  • Received:2011-04-06 Revised:2011-06-24 Online:2011-09-10 Published:2011-08-11
  • Contact: ZHOU Cheng-He E-mail:zhouch@swu.edu.cn
  • Supported by:

    中央高校基本科研业务费专项资金(批准号:   XDJK2009C092)、 国家自然科学基金(批准号:  21172181)和西南大学基金(批准号:  SWUB2006018, XSGX0602)资助.

摘要: 三唑环为含有三个氮原子的五元杂环, 唑环具有芳香性和丰富的电子, 易接受质子和络合金属离子, 因而三唑类化合物易通过配位键、氢键、离子-偶极、阳离子-?、?-?堆积、疏水效应以及范德华力等非共价键力形成超分子聚集体, 表现出许多特殊的性能及生物活性, 具有广泛的潜在应用如作为离子受体、材料、医药等. 近些年来, 相关三唑类超分子化学与医药的研究非常活跃, 发展特别迅速, 已成为十分活跃的热点研究领域. 本文结合自己的工作, 参考国内外近五年文献, 首次系统综述了三唑类化合物作为阳离子和阴离子受体以及三唑类超分子作为发光与磁性材料、医药在抗菌、抗真菌、抗癌等方面的研究与开发近况. 希望本综述对三唑类超分子化学与药物的进一步研发有所启迪.

关键词: 三唑, 超分子, 络合物, 发光材料, 抗癌

Abstract: Triazole ring contains three nitrogen atoms, is a quite important five-member heterocycle and possesses aromaticity and rich electrons. This unique structure endows triazole moiety to readily accept protons and coordinate with various metal ions. Therefore triazole compounds easily form supramolecular aggregates via non-covalent interaction such as coordination bonds, hydrogen bonds, ion-dipole, cation-?, ?-? stacking, hydrophobic effect, van der Waals force and so on. These triazole derivatives exhibit various special properties and biological activities, and display a wide range of potential application as artificial ion receptors, materials and medicinal agents. In recent years, the related researches of triazole-based supramolecular chemistry and medicinal drugs have been becoming an extremely active, quite rapidly developing and attracting highlight area. Combining with authors’ researches and referring other works from literatures in recent 5 years, this work for the first time systematically reviewed the recent advance of the whole range of triazole-based compounds as cation and anion receptors and triazole supermolecules as luminescent and magnetic materials as well as medicinal drugs majoring in antibacterial, antifungal, anticancer agents. Hopefully, this review would be helpful for the further researches and development of the triazole-based supramolecular chemistry and medicinal drugs.

Key words: Triazole, Supermolecule, Complex, Luminescent material, Anticancer

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