高等学校化学学报

高等学校化学学报 ›› 2010, Vol. 31 ›› Issue (8): 1488.

• 研究论文 • 上一篇    下一篇

羟基磷灰石-SOD纳米复合物的合成与性能

吴丽艳1,2, 王悦怡1, 杨东生2, 孟庆繁1, 滕利荣1, 高波1   

  1. 1. 吉林大学生命科学学院, 长春 130012;
    2. 吉林大学珠海学院化学与药学系, 珠海 519041
  • 收稿日期:2010-04-08 出版日期:2010-08-10 发布日期:2010-08-10
  • 通讯作者: 高波, 男, 博士, 教授, 主要从事药物制剂研究. E-mail: gaobo@jlu.edu.cn
  • 基金资助:

    吉林省科技发展计划项目(批准号: 20070312)资助.

In-situ Synthesis and Properties of Hydroxyapatite-SOD Nanocomposite

WU Li-Yan1,2, WANG Yue-Yi1, YANG Dong-Sheng2, MENG Qing-Fan1, TENG Li-Rong1, GAO Bo1*   

  1. 1. College of Life Sciences, Jilin University, Changchun 130012, China;
    2. Department of Chemistry and Pharmacy, Zhuhai College, Jilin University, Zhuhai 519041, China
  • Received:2010-04-08 Online:2010-08-10 Published:2010-08-10
  • Contact: GAO Bo. E-mail: gaobo@jlu.edu.cn
  • Supported by:

    吉林省科技发展计划项目(批准号: 20070312)资助.

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被引次数

3

摘要： 以乙酸钙和磷酸二氢铵为原料, 采用原位合成法一步合成羟基磷灰石(HAP)-超氧化物歧化酶(SOD)纳米复合物(HAP-SOP), 采用傅里叶变换红外光谱、X射线衍射和扫描电镜对复合物进行了表征, 并考察了SOD的活性, 还对各复合物的体外释放行为进行了研究. 结果表明, 合成的HAP-SOD纳米复合物粒径均匀, 粒径在100 nm以下, 包裹后的SOD活性可达84.7%, 且缓释作用明显, 24 h累计释放率为81.2%.

关键词: 羟基磷灰石-超氧化物歧化酶纳米复合物, 原位合成, 蛋白活性, 缓释

Abstract: Hydroxyapatite(HAP)-superoxide dismutase(SOD) nanocomposites(HAP-SOD) were in-situ synthesized using calcium acetate and ammonium dihydrogen phosphate as initial materials and characterized through X-ray diffraction(XRD), Fourier transform infrared spectroscopy(FTIR) and scanning electronic microscopy(SEM). Besides, SOD activity was detected and the release behavior was inspected. The results show that the particle size of HAP-SOD nanocomposite was under 100 nm, and the relative activity of SOD in the composites was up to 84.7%. The cumulative release rate of the complex was up to 81.2% in 24 h.

Key words: HAP-SOD nanocomposite, In-situ synthesis, Protein activity, Sustained-release

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