高等学校化学学报

高等学校化学学报

• 研究论文 • 上一篇    下一篇

CS/TPP纳米微胶囊的制备及其载药性能

杨文静, 王婷, 何农跃   

  1. 东南大学生物电子学国家重点实验室, 南京 210096
  • 收稿日期:2008-07-01 修回日期:1900-01-01 出版日期:2009-03-10 发布日期:2009-03-10
  • 通讯作者: 何农跃

Preparation and Property of Chitosan/Sodium Tripolyphosphate Microcapsules as Drug Carrier

YANG Wen-Jing, WANG Ting, HE Nong-Yue*   

  1. State Key Laboratory of Bioelectronics, Southeast University, Nanjing 210096, China
  • Received:2008-07-01 Revised:1900-01-01 Online:2009-03-10 Published:2009-03-10
  • Contact: HE Nong-Yue

PDF (PC)

被引次数

38

摘要： 利用离子凝胶法, 以三聚磷酸钠(TPP)为交联剂, 由壳聚糖(CS)制备了CS/TPP纳米微胶囊. 用红外光谱仪、扫描电镜和粒径分析仪进行了表征, 并以牛血清蛋白(BSA)作为模型药物, 考察了所制备的CS/TPP纳米微胶囊的包载和缓释性能. 结果表明, CS/TPP纳米微胶囊的红外光谱相对于CS和TPP的红外光谱发生了很大变化, 说明CS和TPP通过正负电荷吸引聚合成囊; 粒径分析表明, 离子凝胶法可以得到粒径约430 nm的均匀分散的壳聚糖纳米微胶囊, 经冷冻干燥后粒径变为300 nm左右; 微胶囊包封率最高可达79.74%, 模型药物的持续释放时间可达7 d以上.

关键词: 壳聚糖, 三聚磷酸钠, 药物缓释

Abstract: Chitosan/sodium tripolyphosphate(CS/TPP) nano-sized microcapsules were prepared with ionic gelation of CS with TPP. The obtained CS nano-sized microcapsules were characterized with the infrared spectra(IR), scanning electron microscope(SEM) and the particle size analyzer. The model protein, bovine serum albumin(BSA) as a model drug, was encapsulated into the CS/TPP nano-sized microcapsules. Infrared spectrum of CS/TPP nano-sized microcapsules indicated that CS was cross-linked with TPP. The average diameter of the obtained nano-sized microcapsules was around 430 nm, and a homogeneous size distribution and good dispersion were observed. BSA-loading efficiency of CS/TPP nano-sized microcapsules did not increase with the increase in concentration of CS. When mass fraction of CS was 0.25%, the highest BSA-loading efficiency of CS/TPP nano-sized microcapsules reached 79.74%, while BSA continually and smoothly released up to one week.

Key words: Chitosan(CS), Sodium tripolyphosphate(TPP), Drug-releasing

中图分类号: 

TrendMD: