高等学校化学学报

高等学校化学学报

• 研究快报 • 上一篇    

两亲三元壳寡糖衍生物的合成及其包合物的研究

赵三平, 曹孟杰, 徐卫林   

  1. 武汉科技学院, 新型纺织材料绿色加工及其功能化教育部重点实验室, 武汉 430073
  • 收稿日期:2008-05-23 修回日期:1900-01-01 出版日期:2008-09-10 发布日期:2008-09-10
  • 通讯作者: 赵三平

Synthesis of Amphiphilic Ternary Chitooligosaccharide Derivatives and Theirs Inclusion Compounds

ZHAO San-Ping*, CAO Meng-Jie, XU Wei-Lin   

  1. Key Laboratory of Green Processing and Functional Textiles of New Textile Materials of Ministry of Education, Wuhan University of Science and Engineering, Wuhan 430073, China
  • Received:2008-05-23 Revised:1900-01-01 Online:2008-09-10 Published:2008-09-10
  • Contact: ZHAO San-Ping

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被引次数

3

摘要： 本文报道了新型水溶性甲氧基聚乙二醇-b-聚己内酯两亲嵌段共聚物接枝壳寡糖(COS-g-PCL-b-MPEG)共聚物的合成, 研究了两亲三元COS衍生物的合成及在水溶液中α-CD与其的包合作用.

关键词: 三元接枝共聚物, 偶联反应, 包合作用, 超分子水凝胶

Abstract: Novel water-soluble amphiphilic ternary graft copolymers(COS-g-PCL-b-MPEG) were synthesized by N,N’-dicyclohexyl carbodiimide(DCC) coupling reaction between chitooligosaccharide(COS) with MPEG-b-PCL-COOH, which was synthesized via ring-opening polymerization of ε-caprolactone(CL) with methoxy poly(ethylene glycol)(MPEG) as an initiator and subsequent carboxylation by succinic anhydride. The che-mical composition of the graft copolymers was studied by 1H NMR spectrum. In aqueous solutions, stable supramolecular hydrogels could be rapidly fabricated via the inclusion compound between the MPEG-b-PCL graft of COS derivates and α-CD. The supramolecular structure of the hydrogels was revealed by WXRD analysis. The temperature sweep test results show that no gel-sol transition temperature appears over the range from 20 ℃ to 60 ℃ for the obtained hydrogels.

Key words: Ternary graft copolymer, Coupling reaction, Inclusion compound, Supramolecular hydrogel

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