高等学校化学学报 ›› 2005, Vol. 26 ›› Issue (12): 2270.

• 研究简报 • 上一篇    下一篇

南中国海星骨海绵Stelletta sp.中的三萜化合物

蓝文健1,林翠梧2,苏镜娱3,曾陇梅3   

  1. 1.中山大学药学院,广州510080;2.广西大学化学与化学工程学院,南宁530004;
    3.中山大学化学与化学工程学院,广州510275
  • 收稿日期:2004-12-28 出版日期:1905-03-14 发布日期:1905-03-14
  • 通讯作者: 曾陇梅(1930年出生),男,教授,博士生导师,从事天然产物化学研究.E-mail:ceszlm@zsu.edu.cn
  • 基金资助:

    国家高科技发展项目(海洋“八六三”计划)(批准号:2001AA620403)及广西省自然科学基金(批准号:0144002)资助.

Triterpenoids from the Sponge Stelletta sp.Collected from the South China Sea

 LAN Wen-Jian1,LIN Cui-Wu2,SU Jing-Yu3,ZENG Long-Mei3*   

  1. 1.School of Pharmaceutical Sciences,Sun Yat-sen University,Guangzhou 510080,China;
    2.School of Chemistry and Chemical Engineering,Guangxi University,Nanning 530004,China;
    3.School of Chemistry and Chemical Engineering,Sun Yat-sen University,Guangzhou 510275,China
  • Received:2004-12-28 Online:1905-03-14 Published:1905-03-14
  • Contact: ZENG Long-Mei;E-mail:ceszlm@zsu.edu.cn

摘要:

最近,我们又从采自广西涠洲岛海域的星骨海绵Stelletta sp.中分离得到3个黄色三萜色素1,2和3(见下式).通过IR,UV,MS和1D NMR,2D NMR等方法测定了它们的结构,并对化合物1的所有C和H进行了指认.同时,通过X射线单晶衍射分析测定了化合物1的立体化学结构.初步的药理实验表明,这3个化合物对P388肿瘤细胞均有很强的抑制活性,ED50值依次为0.01,0.5和1.0μg/mL,提示Stelletta属海绵中的这类三萜具有很好的药用开发前景.

关键词: 海绵;星骨属海绵;三萜化合物;抗肿瘤, 海绵, 星骨属海绵, 三萜化合物, 抗肿瘤

Abstract:

Three isomalabaricane and malabaricane triterpenoids(1-3) were isolated from the sponge Stelletta sp.collected from Weizhou Island,Guangxi Province.The structures of compounds 1-3 were identified mainly by spectroscopic methods and X-ray diffraction analysis.All 1H NMR and 13C NMR signals of compound 1 were assigned for the first time on the basis of HMQC,1H-1H COSY and HMBC experiment.Antitumor assay exhibits that compounds 1,2 and 3 have a significant antitumor activity against P388 tumor cell lines with ED50 values 0.01,0.5,1.0 μg/mL,respectively.

Key words: Sponge; Stelletta sp.; Triterpenoid; Antitumor activity, Sponge, Stelletta sp., Triterpenoid, Antitumor activity

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