高等学校化学学报 ›› 2004, Vol. 25 ›› Issue (6): 1034.

• 研究简报 • 上一篇    下一篇

苯甲酸及其酯类衍生物的分子印迹机理的研究

杨敏莉, 李元宗   

  1. 北京大学化学与分子工程学院, 生物有机与分子工程教育部重点实验室, 北京 100871
  • 收稿日期:2003-08-19 出版日期:2004-06-24 发布日期:2004-06-24
  • 通讯作者: 李元宗(1960年出生),男,教授,博士生导师,从事分子识别与生化分析研究.E-mail:yli@chem.pku.edu.cn E-mail:yli@chem.pku.edu.cn
  • 基金资助:

    国家自然科学基金(批准号:20275002);教育部博士学科点基金资助

Molecular Imprinting Mechanism Study with Benzoic Acid and Ethyl Benzoate Analogues as Templates

YANG Min-Li, LI Yuan-Zong   

  1. Key Laboratory of Bioorganic Chemistry & Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijng 100871, China
  • Received:2003-08-19 Online:2004-06-24 Published:2004-06-24

摘要: 分子印迹聚合物(M IP)是一种具有分子识别能力的新型高分子材料[1~3].对其研究的重要问题之一是如何获得对相应模板化合物具有特异性结合的聚合物,这除了受模板分子结构特征的影响外,同时在很大程度上还受各种聚合物制备条件的影响,比如功能单体[4~6]、溶剂[7]及辅助金属离子的影响[8]等.我们成功地通过计算模板分子与功能单体间的相互作用,预测了一些模板分子的印迹原性(产生印迹效应的性质)的强弱[9],同时对几十种小分子化合物的分子印迹原性与结构之间的关系进行了讨论[10].本文以苯甲酸、对氨基苯甲酸、对羟基苯甲酸及其酯的衍生物(结构见下式)为模板,在不同的功能单体和溶剂体系中制备了相应的分子印迹聚合物,研究了模板分子中不同取代功能基的印迹作用的相对强弱,探讨了功能基的印迹作用强弱与聚合反应体系溶剂极性间的相关性.

关键词: 苯甲酸, 苯甲酸乙酯, 分子印迹聚合物, 印迹原性

Abstract: Molecularly imprinted polymers(MIPs) were synthesized by using derivatives of benzoic acid and ethyl benzoate as the templates. The paper aims at studying the effect of the different functional groups on the imprinting process by summarizing the chromatographic data,and the relationship between the imprinting interaction and the solvents used during the polymerization was discussed. The experimental results show that the structure of the template plays a decisive role in imprinting effect,and imprintogenicity can be improved by changing solvent and monomer for the template. In addition,when carboxy group is replaced by ester group,the templates would lose their imprinting effect completely in acetonitrile;if chloroform is used as porogen,the imprintogenicity of ethyl p-aminobenzoate and ethyl p-hydroxybenzoate will evidently be improved. The result indicates that the solvents used during the polymerization have a great influence on whether the groups of the template can act as effective imprinting groups. Therefore,the solvents should be taken into account in designing the experiments or in theoretical prediction of the imprinting effect of the templates.

Key words: Benzoic acid, Ethyl benzoate, Molecularly imprinted polymer, Imprintogenicity

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