高等学校化学学报

高等学校化学学报 ›› 2003, Vol. 24 ›› Issue (2): 214.

• 研究简报 • 上一篇    下一篇

β-K4H3[SiW9O37(CpTi)3]·11H2O环戊二烯钛多酸衍生物与DNA作用研究

李建新1, 王英2, 王晓红1, 刘巨涛1, 李玉新2, 黄百渠2, 刘景福1   

  1. 1. 东北师范大学化学学院;
    2. 东北师范大学遗传与细胞研究所, 长春 130024
  • 收稿日期:2002-05-27 出版日期:2003-02-24 发布日期:2003-02-24
  • 通讯作者: 刘景福(1932年出生),男,教授,博士生导师,从事多酸化学研究.E-mail:sdjingfu@public.cc.j.lcn E-mail:sdjingfu@public.cc.j.lcn
  • 基金资助:

    国家自然科学基金(批准号:39970824)资助

Investigation on the Interaction of β-K4H3 [SiW9O37(CpTi)3]·11H2O Polyacid Derivative with DNA

LI Jian-Xin1, WANG Ying2, WANG Xiao-Hong1, LIU Ju-Tao1, LI Yu-Xin2, HUANG Bai-Qu2, LIU Jing-Fu1   

  1. 1. Faculty of Chemistry;
    2. Institute of Genetics and Cytology, Northeast Normal University, Changchun 130024, China
  • Received:2002-05-27 Online:2003-02-24 Published:2003-02-24

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关键词: &beta, -K4H3[SiW9O37(CpTi)3]·, 11H20, 琼脂糖凝胶电泳, DNA

Abstract: The interaction between β-K4H3 [SiW9O37(CpTi)3]·11H20 and DNA was investigated by agarose gel electrophoresis. The results suggest that β-K4H3[SiW9O37(CpTi)3]·11H20 can degrade the genomic DNA. The treatment of plasmid DNA with β-K4H3 [SiW9O37(CpTi)3]·11H20 resulted in a fast moving band in front of the three normal conformations(super coiled DNA, linear DNA and relaxed circular DNA) in agarose gel electrophoresis. These results indicate that this chemical material may have the ability to specifically cleavage DNA or to alter conformation of DNA molecules.

Key words: K4H3 [SiW9O37(CpTi)3]·11H20, Agarose gel electrophoresis, DNA

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