高等学校化学学报 ›› 2003, Vol. 24 ›› Issue (11): 2019.

• 研究简报 • 上一篇    下一篇

圆裂短足软珊瑚Cladiella krempfi中的甾醇苷

蓝文健1, 林翠梧1,2, 苏镜娱1, 曾陇梅1   

  1. 1. 中山大学化学与化学工程学院, 广州 510275;
    2. 广西大学化学系, 南宁 530004
  • 收稿日期:2002-10-30 出版日期:2003-11-24 发布日期:2003-11-24
  • 通讯作者: 曾陇梅(1930年出生),男,教授,博士生导师,从事天然有机化学研究.E-mail:ceszlm@zsu.edu.cn E-mail:ceszlm@zsu.edu.cn
  • 基金资助:

    国家自然科学基金(批准号:29932030);国家高科技研究与发展(863)计划资助(批准号:2001AA620403);广西省自然科学基金(批准号:科桂基0144002)资助

Two Steroidal Glycosides from the Soft Coral Cladiella krempfi

LAN Wen-Jian1, LIN Cui-Wu1,2, SU Jing-Yu1, ZENG Long-Mei1   

  1. 1. School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, China;
    2. Department of Chemistry, Guangxi University, Nanning 530004, China
  • Received:2002-10-30 Online:2003-11-24 Published:2003-11-24

关键词: 圆裂短足软珊瑚, 甾醇,

Abstract: Soft corals yield a wide variety of terepenes, steroids and glycosides.The soft coral Cladiella krempfi has been studied by Christopher, and Bheemasankara and five cembanoid diterpenes have been obtained.In our continuing search to discover the bioactive substances from Chinese soft coral, a species of the soft coral Cladiella krempfi collected from Weizhou Island, Guangxi Province were investigated.Two steroidal glycosides 1 and 2 were first isolated from the ethanol extract.On the basis of the spectroscopic methods their structures were established as 3-O-[-D-arabinopyranosyl]-pregn-5,20-dien-3β-ol(1) and {4-O-[β-D-arabinopyranosyl]-pregn-20-en-3β,4α-diol(2)}. Steroidal glycosides were first found from this species of soft coral.Compound 1 was a new compound.Compound 2 was obtained from the South China Sea soft coral, Lobophyton sp.Bioassay showed that compound 2 displayed cytotoxic against human Hep-G2 and Cne2 cell lineSIn vitro with IC 50 values 27.9, 14.3 μg/mLrespectively.

Key words: Soft coral Cladiella krempfi, Sterol, Glycoside

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