高等学校化学学报

高等学校化学学报 ›› 2002, Vol. 23 ›› Issue (1): 1.

• 研究论文 •    下一篇

稀土在鼠肝中的物种分布

卢然1, 朱严楣1, 陈杭亭2, 赵大庆1, 倪嘉缵1, 陈东3, 聂毓秀3   

  1. 1. 中国科学院长春应用化学研究所稀土化学物理开放实验室;
    2. 国家电分析和光谱研究测试中心, 长春 130022;
    3. 林大学基础医学院组织学与胚胎学教研室, 长春 130021
  • 收稿日期:2001-02-23 出版日期:2002-01-24 发布日期:2002-01-24
  • 通讯作者: 赵大庆(1963年出生),博士,研究员,博士生导师,从事生物无机化学及分子生物学研究.
  • 基金资助:

    国家自然科学基金重大项目(批准号:29890280);国家博士后科学基金资助

Species of Rare Earth in Rat Liver

LU Ran1, ZHU Yan-Mei1, CHEN Hang-Ting2, ZHAO Da-Qing1, NI Jia-Zuan1, CHEN Dong3, NIE Yu-Xiu3   

  1. 1. Key Laboratoryof Rare Earth Chemistryand Physics;
    2. National Analytical Research Center of Electrochemistry and Spectroscopy, Changchun Instituteof App lied Chemistry, Chinese Academy of Sciences, Changchun 130022, China;
    3. Departmentof Histology and Embryology, School of Basic Medical Science, Jilin University, Changchun 130021, China
  • Received:2001-02-23 Online:2002-01-24 Published:2002-01-24

PDF (PC)

被引次数

19

摘要： 采用ICP-MS、微量蛋白层析分离技术,研究了长时间、低剂量混合稀土及短时间、高剂量硝酸镧分别对大鼠及小鼠作用后,稀土在鼠肝中的代谢累积及其物种分布.结果表明,鼠肝中各稀土含量随给药剂量的增加而增大,其累积速度大小顺序为La>Ce>Nd>Pr;经柱层析分离未得到与稀土特异结合的鼠肝蛋白;稀土可与多种鼠肝蛋白(包括多种重要的酶)结合,在一定条件下,稀土与其结合蛋白可发生解离.

关键词: 稀土, 肝脏, 物种分布, ICP-MS

Abstract: The metabolic accumulation and species of rare earth in rat liver were investigated by ICP-MS and chromatography after the rats were fed by a low dose of mixed rare earth for a long time or the administration of a high dose of lanthanum for a short time. It was found that the content of rare earth in the liver increased with the arising of dose of drug delivery. Their accumulation rate was different, for example, La>Ce>Nd>Pr. The protein which could combine with rare earth specially were not gotten through chromatography. It was suggested that rare earth could bind to many proteins voluntarily, such as some important enzymes and it might be separated from the combined proteins under certain conditions.

Key words: Rare Earth, Liver, Species distribution, ICP-MS

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