高等学校化学学报

高等学校化学学报 ›› 2001, Vol. 22 ›› Issue (6): 939.

• 研究论文 • 上一篇    下一篇

含吡唑环的双杂环化合物的合成及其生物活性

赵卫光, 陈寒松, 李正名, 韩玉芬, 颜寒, 赖俊英, 王素华   

  1. 南开大学元素有机化学研究所, 天津 300071
  • 收稿日期:2000-05-15 出版日期:2001-06-24 发布日期:2001-06-24
  • 通讯作者: 李正名(1931年出生),男,教授,博士生导师,中国工程院院士,主要从事有机化学和新农药的研究.
  • 基金资助:

    国家自然科学基金重点项目(批准号:298302050)资助

Synthesis of Pyrazolyl-heterocycles and Their Fungicidal Activities

ZHAO WeiGuang, CHEN Han-Song, LI Zheng-Ming, HAN Yu-Fen, YAN Han, LAI Jun-Ying, WANG Su-Hua   

  1. Institute of Elemento organic Chemistry, Nankai Universty, Tianjin 300071, China
  • Received:2000-05-15 Online:2001-06-24 Published:2001-06-24

PDF (PC)

被引次数

77

摘要： 以4-硝基-5-吡唑甲酰肼为起始物,合成了一系列含硝基的5-吡唑基-1,3,4-噁二唑类、5-吡唑基-1,3,4-噻二唑类和5-吡唑基-1,3,4-三唑类的化合物.初步生测结果表明:部分化合物有较好的杀菌和内吸活性.

关键词: 吡唑, 1, 3, 4-噁二唑, 1, 3, 4-噻二唑, 1, 3, 4-三唑, 杀菌活性

Abstract: Aseries of pyrazolyl heterocycles, including1,3,4thiodiazoles, 1,3,4-oxadiazoles and 1,3,4-triazoles were synthesized from 4-nitro pyrazole formhydrazide. The structures of all new compounds were confirmed by 1H NMRand elementary analysis. Their fungicidal activity was evaluated against Rhizoctonia solani. Structure activity relationships for the screened compounds were evaluated and discussed. It was found that some compounds showed a higher fungicidal activity and systematic activity.

Key words: Pyrazole, 1,3,4-Thiodiazole, 1,3,4-Oxadiazole, 1,3,4-Triazole, Fungicidal activity

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