高等学校化学学报 ›› 2001, Vol. 22 ›› Issue (2): 223.

• 研究论文 • 上一篇    下一篇

手性Salen-Cu(Ⅱ)和噁唑啉-Cu(Ⅱ)配合物催化2-苯基环己酮的不对称Baeyer-Villiger反应研究

彭云贵2, 冯小明1,2, 王斌2, 李智2, 杨桂树2, 蒋耀忠2   

  1. 1. 四川大学化学学院, 成都 610064;
    2. 中国科学院成都有机化学研究所不对称合成联合开放实验室, 成都 610041
  • 收稿日期:1999-08-31 出版日期:2001-02-24 发布日期:2001-02-24
  • 通讯作者: 冯小明(1964年出生),男,博士,教授,博士生导师,从事有机化合物不对称合成研究.E-mail:ulas@cioc.ac.cn E-mail:ulas@cioc.ac.cn
  • 基金资助:

    国家自然科学基金(批准号:29832020)资助

A Study of Asymmetric Baeyer-Villiger Reaction of 2-Phenylcyclohexanone Catalyzed by Chiral Salen-Cu(Ⅱ) and Oxazoline-Cu(Ⅱ) Complexes

PENG Yun-Gui2, FENG Xiao-Ming1,2, WANG Bin2, LI Zhi2, YANG Gui-Shu2, JIANG Yao-Zhong2   

  1. 1. Shanghai Institute of Organic Chemistry, Academia Sinica, Shanghai 200032, China;
    2. Institute of Pharmacology and Toxicology Academy of Military Medical Sciences, Beijing 100050, China
  • Received:1999-08-31 Online:2001-02-24 Published:2001-02-24

摘要: 对一系列手性Salen和唑啉配体与中心金属Cu(Ⅱ)的配合物催化2苯基环己酮的不对称BaeyerVilliger反应进行了研究,设计和合成了新型手性配体Ⅲ,Ⅳ,Ⅴ,对配合物ⅤCu(Ⅱ)进行了单晶X射线衍射分析.并考察了助氧化剂、溶剂等对反应活性和选择性的影响.

关键词: 不对称催化, Baeyer-Villiger反应, 手性配体

Abstract: In this paper, we have studied the asymmetric Baeyer-Villiger reaction of 2-phenylcyclohexanone catalyzed by Cu(Ⅱ) complexes which derived from a series of chiral Salen and oxazoline ligands, as well as designed and synthesized the new chiral ligands Ⅲ, Ⅳ, Ⅴ. And the configuration of complex Ⅴ-Cu(Ⅱ) was determined by X-ray analysis. We also investigated the influence of co-oxidant, solvent, etc. on the reactivity and selectivity.

Key words: Asymmetric catalysis, Baeyer-Villiger reaction, Chiral ligand

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