高等学校化学学报

高等学校化学学报 ›› 2001, Vol. 22 ›› Issue (12): 2040.

• 研究简报 • 上一篇    下一篇

从四氢叶酸辅酶模型合成麝香酮中间体2,15-十六二酮

白银娟, 卢林刚, 史真   

  1. 西北大学化学系, 西安 710069
  • 收稿日期:2000-09-04 出版日期:2001-12-24 发布日期:2001-12-24
  • 通讯作者: 白银娟(1967年出生),女,硕士,讲师,从事有机合成研究.E-mail:lujunyue@hotmail.com E-mail:lujunyue@hotmail.com
  • 基金资助:

    西北大学科研基金(批准号:99NW48)资助

Synthesis of Muscone Mediator 2,15-Hexadecanedione from Tetrahydrofolate Coenzyme Model

BAI YinJuan, LU Lin Gang, SHI Zhen   

  1. Department of Chemistry, Northwest University, Xi'an 710069, China
  • Received:2000-09-04 Online:2001-12-24 Published:2001-12-24

PDF (PC)

被引次数

6

关键词: 麝香酮, 2, 15-十六二酮, 咪唑啉盐

Abstract: Anew synthetic method of 2,15 hexadecanedione from imidazalium salt and di Grignard reagent is reported. Imidazalium salt was used as tetrahydrofolate coenzyme model at formic acid oxidation level and di Grignard reagent as a nucleophile to which one carbon unit was transferred, the biomimetic synthesis of 2,15 hexadecanedione, a precursor of 3 methylcyclopentadecanone(muscon), was successfully accomplished by using the addition hydrolysis reaction of imidazolium salt with di Grignard reagent.

Key words: Muscone, 2,15 Hexadecanedione, Imidazolium salt

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