高等学校化学学报

高等学校化学学报 ›› 2000, Vol. 21 ›› Issue (1): 79.

• 研究快报 • 上一篇    下一篇

NAD(P)H模型引发的还原环化——2,2-双取代1,2-二氢茚的合成

王宏义1, 刘有成1,2, 郭庆祥2   

  1. 1. 兰州大学应用有机化学国家重点实验室, 化学系, 兰州 730000;
    2. 中国科学技术大学化学系, 合肥 230026
  • 收稿日期:1999-06-26 出版日期:2000-01-24 发布日期:2000-01-24
  • 通讯作者: 刘有成(1920年出生),男,博士,教授,中国科学院院士,从事物理有机化学研究.
  • 基金资助:

    国家自然科学基金(批准号:29832040)资助

Reductive Cyclization Initiated by an NAD(P)H Model——Synthesis of 2,2-Disubstituted Indanes

WANG Hong-Yi1, LIU You-Cheng1,2, GUO Qing-Xiang2   

  1. 1. National Laboratory of Applied Organic Chemistry and Department of Chemistry, Lanzhou University, Lanzhou 730000, China;
    2. Departmentof Chemistry, Universityof Scienceand Technology of China, Hefei 230026, China
  • Received:1999-06-26 Online:2000-01-24 Published:2000-01-24

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关键词: NAD(P)H模型, 还原环化, 2, 2-双取代1, 2-二氢茚

Abstract: A facile synthesis of 2,2-disubstituted idanes was achieved by the reductive cyclization of 1-(o-bromomethylphenyl)-2,2-disubstituted-ethylenes(electron-withdrawing substituents) with an NAD(P)H model, 1-benzyl-1,4-dihydronicotinamide, in yields from moderate to good. The study revealed that 1-benzyl-1,4-dihydronicotinamide can be used in synthetic organic chemistry as an effective reductant.

Key words: NAD(P)H model, Reductive cyclization, 2,2-Disubstituted indanes

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