高等学校化学学报

高等学校化学学报 ›› 1999, Vol. 20 ›› Issue (10): 1646.

• 论文 • 上一篇    下一篇

丝素蛋白膜上5-氟尿嘧啶的包埋及其释放

陈建勇1, 刘冠峰1, 沈之荃2   

  1. 1. 浙江丝绸工学院纤维分院, 杭州 310033;
    2. 浙江大学高分子科学与工程系, 杭州 310027
  • 收稿日期:1998-10-05 出版日期:1999-10-24 发布日期:1999-10-24
  • 通讯作者: 陈建勇,男,40岁,教授,博士研究生.
  • 作者简介:陈建勇,男,40岁,教授,博士研究生.
  • 基金资助:

    浙江省跨世纪学术和技术带头人培养基金

Embedment and Deliverance of 5-Fluorouracil from Blended Membrane of Silk Fibroin and 5-Fluorouracil

CHEN Jian-Yong1, LIU Guan-Feng1, SHEN Zhi-Quan2   

  1. 1. College of Textile Technology, Zhejiang Silk Institute of Technology, Hangzhou 310033, China;
    2. Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China
  • Received:1998-10-05 Online:1999-10-24 Published:1999-10-24

PDF (PC)

被引次数

57

摘要： 讨论了包埋在丝素膜中的5-氟脲嘧啶(5-FU)的固定状况,在不同pH值下测定了丝素5-FU复合膜中药物的释放.实验结果表明:5-FU可以均匀地被包埋在丝素膜中,即丝素膜可以作为5-FU载体.经过丝素涂层保护,丝素5-FU复合膜中的5-FU溶解释放速率变慢,释放时间延长;经涂层的丝素5-FU复合膜在接近丝素蛋白等电点(pH=4.5)时,5-FU在溶液中释放速度较慢,释放时间较长,表明用调节外部溶液pH值的方法可以调控5-FU的释放速度.

关键词: 丝素膜, 5-氟尿嘧啶, 药物载体, 缓释

Abstract: The silk fibroin membrane is an amphoteric ion-exchange membrane composed of both weak acidic and weak basic groups. 5-FluorouraciLIs an anti-cancer drug. The condition of 5-fluorouracil blended into silk fibroin membrane has been investigated, then deliverance of 5-fluorouracil from blended membrane of silk fibroin and 5-fluorouracil was measured in the pH range from 3 to 9. The results of SEM, FTIR, DSC show that 5-fluorouracil could be evenly blended into silk fibroin protein. After coating with silk fibroin, the dissolve rate of 5-fluorouracil fixed on silk fibroin and 5-fluorouracil blended membrane could be descended, and the delivery time of 5-fluorouracil could be prolonged. The delivery time and dissolve rate also depends on pHvalues of soaking solution. It is expected that silk fibroin membrane could be used as the matrix of 5-fluorouracil delivery system.

Key words: Silk fibroin membrane, 5-Fluorouracil, Drug matrix, Deliverance

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