高等学校化学学报

高等学校化学学报 ›› 1998, Vol. 19 ›› Issue (9): 1383.

• 论文 • 上一篇    下一篇

一种新的甲硝唑荧光光纤传感器的研制

唐江宏1, 贺萍2, 刘万卉2, 沈国励1, 俞汝勤1   

  1. 1. 湖南大学化学化工学院, 化学计量学与化学传感技术研究所, 长沙, 410082;
    2. 烟台大学应用化学系, 烟台, 264005
  • 收稿日期:1998-01-04 出版日期:1998-09-24 发布日期:1998-09-24
  • 通讯作者: 沈国励
  • 作者简介:唐江宏,男,33岁,讲师,河南平顶山师专访问学者.
  • 基金资助:

    国家教育委员会博士点(批准号:9553201)基金和机械工业部技术发展基金(批准号:96-6)资助课题.

A New Fluorescence Optic fiber Sensor for Metronidazole

TANG Jiang-Hong1, HE Ping2, LIU Wan-Hui2, SHEN Guo-Li1, YU Ru-Qin1   

  1. 1. College of Chemistry and Chemical Engineering, Institute of Chemometrics and Chemical Sensing Technology, Hunan University, Changsha, 10082;
    2. Department of Applied Chemisttry, Yantai University, Yantai, 264005
  • Received:1998-01-04 Online:1998-09-24 Published:1998-09-24

PDF (PC)

被引次数

6

摘要： 将1,4-二(苯并(噁)唑-1',3'-基-2')苯(BBOB)包埋在增塑的聚氯乙烯膜中,研制了一种新的荧光猝灭型甲硝唑光纤传感器.猝灭机制包括甲硝唑的初级内滤效应和甲硝唑与BBOB形成电荷转移复合物两种作用.传感器可逆性好,响应时间小于30s,响应线性范围是4.00×10-6～1.00×10-4mol/L,检测限为1.00×10-6mol/L,对1.00×10-4mol/L甲硝唑的相对偏差为0.82%(n=10).常见的无机离子、药物不影响甲硝唑的测定,对商品制剂中甲硝唑的测定结果与药典法一致.

关键词: 甲硝唑, 1, 4-二(苯并号(噁)唑-1', 3'-基-2')苯, 荧光光纤传感器

Abstract: Afluorophore of 1,4-bis(1,3-benzoxazol-2-yl)benzene(BBOB) was selected as sensing molecule for constructing a new metronidazole optic-fiber sensor. The sensing performence is based on the fluorescence quenching of the plasticized PVCoptode membrane trapped with BBOBby metronidazole. The quenching mechanism includes a primary inner filter effect and the formation of a charge-transfer complex between BBOBand metronidazole extracted from aqueous phase into membrane phase. In the range of 4.00×10-6～1.00×10-4 mol/L, the sensor responds linearly to metronidazole with a detection limit of 1.0×10-6 mol/Lmetronidazole. Agood reversibility and a rapid response within 30s were obtained. The relative standard deviation of repeating measurements of 1.00×10-4 mol/Lmetronidazole is 0.82%( n =10). The sensor shows good selectivity over the common inorganic ions and pharmaceutical species and therefore can be used for the direct determination of metronidazole in commercial preparations, the results were in agreement with those obtained by pharmacopoeia method.

Key words: Metronidazole, 1,4-Bis(1,3-benzoxazol-2-yl)benzene, Optic fiber sensor

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