高等学校化学学报 ›› 1998, Vol. 19 ›› Issue (4): 577.

• 研究简报 • 上一篇    下一篇

2-酰肼基-5-(2,4-二氯苯基)-1,3,4-噁二唑的合成及环化反应研究

冯小明, 何勋, 蒋耀忠   

  1. 中国科学院成都有机化学研究所不对称合成联合开放实验室, 成都, 610041
  • 收稿日期:1997-04-19 出版日期:1998-04-24 发布日期:1998-04-24
  • 通讯作者: 冯小明,男,33岁,博士,研究员.
  • 作者简介:冯小明,男,33岁,博士,研究员.

Synthesis of 3-Acylhydrazino-5-(2,4-dichlorophenyl)-1,3,4-oxadiazole and Studies on Their Cyclization

FENG Xiao-Ming, HE Xun, JIANG Yao-Zhong   

  1. Union Laboratory of Asymmetric Synthesis, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu, 610041
  • Received:1997-04-19 Online:1998-04-24 Published:1998-04-24

关键词: 2, 5-二取代-1, 3, 4-噁二唑, 3, 6-二取代基-S-三唑[3, 4-b]-1, 3, 4-噁二唑, 环化反应

Abstract: Fourteen new 2-acylhydrazino-5-(2,4-dichlorophenyl)-1,3,4-oxadiazoles were prepared by nucleophilic displacement of acylhydrazine at the 2-position of 2-methylsulfonyl-5-(2,4-dichlorophenyl)-1,3,4-oxadiazole . Fourteen new 3-substituted-6-(2,4-dichloro-phenyl)-S-triazolo-1,3,4-oxadiazoles were obtained by treating 2-acylhydrazino-5-(2,4-dichloro phenyl)-1,3,4-oxadiazoles with K2CO3 solution. The structures of new compounds were determined by elementary and spectral analyses. All the new compounds showed a significant antibacterial activity.

Key words: 2,5-Disubstituted-1,3,4-oxadiazole, 3,6-Disubstituted-S-triazolo[3,4-b], 1,3,4-oxadiazole, Cyclization

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