高等学校化学学报 ›› 1998, Vol. 19 ›› Issue (10): 1602.

• 综合评述 • 上一篇    下一篇

在有机溶剂中进行酶催化合成肽及肽类衍生物的研究进展

邢国文, 叶蕴华, 李崇熙   

  1. 北京大学化学与分子工程学院, 北京, 100871
  • 收稿日期:1997-11-24 出版日期:1998-10-24 发布日期:1998-10-24
  • 通讯作者: 叶蕴华.
  • 作者简介:邢国文,男,24岁,博士研究生.
  • 基金资助:

    国家自然科学基金(批准号:29772001)资助课题.

Progress in Enzymatic Syntheses of Peptides and Peptide Derivatives in Organic Solvents

XING Guo-Wen, YE Yun-Hua, LI Chong-Xi   

  1. College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871
  • Received:1997-11-24 Online:1998-10-24 Published:1998-10-24

摘要: 介绍了有机溶剂中含非天然组分的肽及肽类衍生物的酶催化反应,同时对研究有机溶剂中酶的活性与结构关系的谱学技术进行了评述.

关键词: 蛋白酶, 酶催化反应, 肽, 肽类衍生物, 有机溶剂

Abstract: More attention has been focused on the enzymatic reaction in organic solvents in recent years. In this paper, syntheses of peptides and peptide derivatives containing unnatural constituent catalyzed by proteases and lipase were introduced. The influence of reaction conditions on the enzymatic synthesis and its application to the preparation of cyclopeptide and polypeptide were reviewed. The study of relationship between enzyme activity and its structure through modern spectroscopy was also discussed.

Key words: Protease, Enzymatic reaction, Peptides, Peptide derivatives, Organic solvent

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