高等学校化学学报

高等学校化学学报 ›› 1997, Vol. 18 ›› Issue (4): 550.

• 论文 • 上一篇    下一篇

3-芳基-5-巯基-1,2,4-均三唑的双-Mannich反应研究

王忠义1, 尤田耙1, 史海健2, 史好新2   

  1. 1. 中国科技大学化学物理系, 合肥, 230026;
    2. 安徽师范大学化学系, 芜湖, 241000
  • 收稿日期:1996-05-23 出版日期:1997-05-24 发布日期:1997-05-24
  • 通讯作者: 王忠义, 男. 32岁, 博士, 副教授.
  • 作者简介:王忠义, 男. 32岁, 博士, 副教授.
  • 基金资助:

    安徽省教育委员会和科学技术委员会自然科学基金

Studies on Double Mannich Reaction of 3-Aryl-5-mercapto-1, 2, 4-triazoles

WANG Zhong-Yi1, YOU Tian-Pa1, SHI Hai-Jian2, SHI Hao-Xin2   

  1. 1. Department of Chemical Physics, University of Science and Technology of China, Hefei, 230026;
    2. Department of Chemistry, Anhui Normal University, Wuhu, 241000
  • Received:1996-05-23 Online:1997-05-24 Published:1997-05-24

PDF (PC)

被引次数

11

摘要： 研究了在氯化氢-乙醇溶液中,3-芳基-5-巯基-1,2,4-均三唑与甲醛和伯胺(芳胺或脂肪胺)的双Mannich反应,合成了13种新的稠杂环化合物3,5-二取代-四氢均三唑并[3,4-b][1,3,5]噻二嗪.经元素分析、IR、1H NMR和MS确定了产物的结构,初步测定了该类化合物的生物活性.

关键词: 3-芳基-5-巯基-1, 2, 4-均三唑, 3, 5-二取代四氢均三唑并[3, 4-b][1, 3, 5]噻二嗪, Mannich碱, 生物活性

Abstract: In this paper, thirteen new 3, 5-disubstltuted tetrahydro-s-triazolo [3'4-b][1'3,5]thiadiazines were prepared by double Mannich reaction in the presence of HCl-ethanol so-lution, arylamine-HCl and 37% aqueous formaldehyde solution or the condensation productof arylamine and para formaldehyde were reacted with 3-aryl-5-mercapto-1, 2, 4-triazole toform the title compounds at 45-65℃.The structure of these compounds were characterizedby elementary analysis, IR, 1H NMRand MS.Their antibactericidal activity against E.Col-i, B-Subtilis and S.Aureus were tested.

Key words: 3-Aryl-5-mercapto-1,2,4-triazoles,3,5-Disubstituted tetrahydro-s-triazoio[3,4-b][1,5]thiadiazine, Mannich base, Biological activity

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