高等学校化学学报

高等学校化学学报 ›› 1997, Vol. 18 ›› Issue (3): 409.

• 论文 • 上一篇    下一篇

1-芳酰基-4-取代吡唑甲酰基氨基硫脲和环化产物的合成及生物活性

金桂玉, 侯震, 赵国锋, 曹春阳, 李煜昶   

  1. 南开大学元素有机化学研究所, 天津, 300071
  • 收稿日期:1996-04-19 出版日期:1997-03-24 发布日期:1997-03-24
  • 通讯作者: 金桂玉, 女, 60岁, 教授,
  • 作者简介:金桂玉, 女, 60岁, 教授,
  • 基金资助:

    国家自然科学基金

The Synthesis and Biological Activity of 1-Aryl-4-substituted Pyrazoloyl Thiosemicarbazides and Related Heterocyclic Compounds

JIN Gui-Yu, HOU Zhen, ZHAO Guo-Feng, CAO Chun-Yang, LI Yu-Chang   

  1. Institute of Elemento-organic Chemistry, Nankai University, Tianjin, 300071
  • Received:1996-04-19 Online:1997-03-24 Published:1997-03-24

PDF (PC)

被引次数

187

摘要： 利用1-苯基-3-甲基-5-氯-4-吡唑甲酰基异硫氰酸酯(Ⅰ)与芳酰肼(Ⅱ)的加成反应合成了系列新的酰胺基硫脲衍生物(Ⅲ),并将Ⅲ在酸性条件下进行环化反应得到2-取代吡唑甲酰基氨基-5-芳基-1,3,4-噻二唑(Ⅳ).生物活性测定结果表明部分化合物Ⅲ和Ⅳ具有较好的除草活性.

关键词: 1-苯基-3-甲基-5-氧-4-吡唑甲酰基异硫氰酸酯, 芳基酰肼, 酸胺基硫脲, 1, 3, 4-噻二唑, 除草活性

Abstract: Aseries of new acylthiosemicarbazide derivatives (Ⅲ) were synthesized by addition reaction of 1-phenyl-3-methyl-5-chloro-4-pyrazoloyl isthiocyanate (Ⅰ) with aroyl hydrazines (Ⅱ), which were cyclized under an acidic condition to obtain 2-substituted pyrazoloyl amino-5-aryl-1, 3, 4-thiadiazoles (Ⅳ).The preliminary biological tests indicate thatsome compounds of Ⅲ and Ⅳ show a good herbicidal activity.

Key words: 1-Phenyl-3-methyl-5-chloro-4-pyrazoloyl isothiocyanate, Aroyl hydrazine, Acyl thiosemicarbazide, 1,3,4-Thiadiazole, Herbicidal activity

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