高等学校化学学报 ›› 1995, Vol. 16 ›› Issue (5): 735.

• 论文 • 上一篇    下一篇

α-取代乙酰胺类化合物结构与除草活性的构效关系研究

杨华铮, 李全仲, 程慕如, 任康太   

  1. 南开大学元素有机化学研究所, 国家元素有机化学重点实验室, 天津, 300071
  • 收稿日期:1994-05-30 修回日期:1995-02-21 出版日期:1995-05-24 发布日期:1995-05-24
  • 通讯作者: 杨华铮,女,58岁,教授,博士导师.
  • 作者简介:杨华铮,女,58岁,教授,博士导师.
  • 基金资助:

    国家自然科学基金

Quantitative Structure-Activity Relationship Studyof Herbicidal α-Substituted Acetamides

YANG Hua-Zheng, LI Quan-Zhong, CHENG Mu-Ru, REN Kang-Tai   

  1. Institute of Eleniento-Organic Chemistry, National Key Laboratory ofElernento-Organic Chemistry, Nankai University, Tianjin, 300071
  • Received:1994-05-30 Revised:1995-02-21 Online:1995-05-24 Published:1995-05-24

摘要: 分别研究了N,N-二取代-α-氯代乙酰胺类化合物及N,N-二取代-α-二硫代磷酰基乙酰胺类化合物结构与除草活性的定量关系。结果表明:氮原子上取代基的大小对两类化合物的除草活性具有相同的影响,只是最适宜的疏水性不同,两类化合物可能具有相同的作用机制。

关键词: 取代乙酰胺, 除草活性, 构效关系, 回归分析

Abstract: The quantitative relationship between the structures of N, N-disubstituted-α-chloroacetamide and α-(O,O-dialkyl phosphorodithioy) acetamide and their herbicidal activi ty on the barnyard grass,Echinochloa cruss-galli, was analyzed respectively. We found that their hydrophobicity and steric dimension of substituted amino group strongly affect their herbicidal activity. In two QSAR equations, the optimum steric dimension values (B1) were approximate, but their optimum hydrophobicity values (π) differ from each other.It was suggested that there may be the same mode of action for the two kinds of compounds.

Key words: Substituted acetamide, Herbicidal activity, QSAR, Regression analysis

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