高等学校化学学报

高等学校化学学报 ›› 1995, Vol. 16 ›› Issue (3): 391.

• 论文 • 上一篇    下一篇

反式硫代环磷酰基硫脲的合成及性质研究

邵瑞链, 杨光富, 苗伟时, 李广仁   

  1. 南开大学元素有机化学研究所, 天津 300071
  • 收稿日期:1994-03-12 修回日期:1994-09-06 出版日期:1995-03-24 发布日期:1995-03-24
  • 通讯作者: 杨光富
  • 作者简介:邵瑞链,女,54岁,教授.
  • 基金资助:

    国家自然科学基金

Studies on the Syntheses and Biological Activties of trans-Cyclothiophosphorylthioureas

SHAO Rui-Lian, YANG Guang-Fu, MIAO Wei-Shi, LI Guang-Ren   

  1. Institute of Elemento-Organic Chemistry, Nankai University, Tianjin 300071
  • Received:1994-03-12 Revised:1994-09-06 Online:1995-03-24 Published:1995-03-24

PDF (PC)

被引次数

8

摘要： 采用反式2-异硫氰基-4-苯基-5,5-二甲基-2-硫代-1,3,2-二氧磷杂环己烷与不同胺的加成反应合成了13个新型的反式环状硫代磷酸基硫脲衍生物。生物活性初步测试表明,部分化合物具有杀菌及植物生长调节活性。本文首次报道了2-氯-4-苯基-5,5-二甲基-2-硫代-1,3,2-二氧磷杂环己烷与硫氰酸钾反应的立体化学。

关键词: 1, 3, 2-二氧磷杂环己烷, 硫脲, 立体化学, 非对映异构体, 生物活性

Abstract: Thirteen new trans-cyclothiophosphorylthiourea derivatives,R1R2NC(S) NHR3(R1=H,alkyl;R2=alkyl, substituted plienyl;R3=4-phenyl-5,5-dimethyl-2-sulfo-1,3,2-dioxaphosplioranyl),were synthesized by the addition reaction of frans-2-isothiocyano-4-plienyl-5,5-dimethyl-2-sulfo-1,3,2-dioxaphosphorinane to various amines respectively and their structure were confirmed by means of elemental analysis,1HNMR and IR. The biological activities of all new compounds were tedsted preliminarily and the results indicate that some compounds showed fungicidal activity and plant-growth reguiarity activity. In addition,the stereochemistry of the reaction between 2-chloro-4-phenyl-5,5-dimethyl-2-sulfo-1,3,2-dioxaphosphorinane and potassium thiocyanate was reported for the first time.

Key words: 1,3,2-Dioxaphosphorinane, Thiourea, Stereochemistry, Diastereoisomer, Biological activity

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