高等学校化学学报 ›› 1994, Vol. 15 ›› Issue (7): 1009.

• 论文 • 上一篇    下一篇

芳基肟胺菊酯类化合物和1,2,4-噁二唑衍生物的合成及其生物活性研究

金桂玉, 赵国锋, 郑健禺   

  1. 南开大学元素有机化学研究所, 天津, 300071
  • 收稿日期:1993-08-26 修回日期:1994-03-22 出版日期:1994-07-24 发布日期:1994-07-24
  • 通讯作者: 金桂玉,女,58岁,教授.
  • 作者简介:金桂玉,女,58岁,教授.
  • 基金资助:

    国家自然科学基金

Studies on the Synthesis and Biological Activities of Aryl Amidoximyl Chrysanthemumates and 1,2,4-Oxadiazole Derivatives

JIN Gui-Yu, ZHAO Guo-Feng, ZHENG Jian-Yu   

  1. Institute of Elemento-Organic Chemistry, Nankai Univcrsity, Tianjin, 300071
  • Received:1993-08-26 Revised:1994-03-22 Online:1994-07-24 Published:1994-07-24

摘要: 芳基肟胺化合物与取代环丙烷羧酸酰氯在Et3N作用下室温反应得到芳基肟胺菊酯类化合物,在甲苯中回流反应则得到含取代环丙烷基的1,2,4-二唑衍生物。前者在甲苯中回流,HOAc作催化剂时发生环化反应也生成1,2,4-二唑衍生物。初步生物活性测试表明这些化合物具有的杀菌和除草活性。

关键词: 芳基肟胺菊酯, 1, 2, 4-噁二唑, 环化反应, 生物活性

Abstract: Aryl amidoximes reacted with substituted cyclopropane carbonyl chlorides under the action of Et3Nin room temperature to give aryl amidoximyl chrysanthemumates and under reflux in toluene to give 1, 2, 4-oxadiazole derivatives.When the formers reacted under reflux in toluene using HOAc as catalysis, the cyclization took place and 1, 2, 4-oxadiazole derivatives were also obtained.The preliminary biological tests indicated that these compounds had fungicidal and herbicidal activities.

Key words: Aryl amidoximyl chrysanthemumate, 1,2,4-Oxadiazole, Cyclization reaction, Biological activity

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