高等学校化学学报

高等学校化学学报 ›› 1993, Vol. 14 ›› Issue (9): 1254.

• 研究简报 • 上一篇    下一篇

1,2,4-三嗪类化合物的研究(ⅩⅩ)——利用波谱分析确定3-甲硫基-5-羟基-1,2,4-三嗪的取代苯磺酰化反应及其产物的结构

韩梅, 施栩翎, 杨振军, 蔡孟深, 程铁明   

  1. 北京医科大学药学院, 北京 100083
  • 收稿日期:1992-12-05 修回日期:1993-05-10 出版日期:1993-09-24 发布日期:1993-09-24
  • 通讯作者: 程铁明.
  • 作者简介:第一作者:女, 31岁, 硕士, 讲师.
  • 基金资助:

    国家自然科学基金

A Study of 1,2,4-Triazines (XX) ——Study on Structures of Products from a Series of Substituted Benzene Sulfonation of 3-Methylthio-5-hydroxy-1,2,4-triazine by Spectrum Analysis

HAN Mei, SHI Xu-Ling, YANG Zhen-Jun, CAI Meng-Shen, CHENG Tie-Ming   

  1. School of Pharmaceutical Sciences, Beijing Medical University, Beijing, 100083
  • Received:1992-12-05 Revised:1993-05-10 Online:1993-09-24 Published:1993-09-24

PDF (PC)

关键词: 1, 2, 4-三嗪, 取代苯磺酰化, 1H NMR, 13C NMR, 结构鉴定

Abstract: This paper reported the reaction between 3-methylthio-5-hydroxy-1,2,4-triazine (1) and subsitituted benzene sulfochlorides (p-CH3, p-Br, m-NO2).The structures of the products were identified as 3-methylthio-4-subsituted benzene sulfonyl-5-oxo-6-hydroxy-1, 4, 5, 6-te-trahydro-1,2,4-triazine by 1H NMRand 13C NMRas well as UV.The analysis results show the compounds proceeded both a substituted benzene monosulfonation to N4 position (not to N2 or C5-OH) and addition of one molecule H2Oto-N1 = C6- double bond in which the hydroxy group was connected to C6 position.

Key words: 1,2,4-Triazine, Substituted benzene sulfonation, 1H NMR, 13C NMR, Determination of structure

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