高等学校化学学报

高等学校化学学报 ›› 1993, Vol. 14 ›› Issue (10): 1383.

• 研究论文 • 上一篇    下一篇

(3-苄基-4-芳酰基-1,2,4-三唑-5-基)(5-本基-1,3,4-噁二唑-2-基)硫醚的合成

冯小明1, 陈荣1, 张自义2   

  1. 1. 西南师范大学化学系, 重庆 630715;
    2. 兰州大学化学系
  • 收稿日期:1992-11-27 修回日期:1993-05-03 出版日期:1993-10-24 发布日期:1993-10-24
  • 通讯作者: 冯小明, 男, 29岁, 副教授.
  • 作者简介:冯小明, 男, 29岁, 副教授.

Syntheses of (3-Benzyl-4-aroyl-l,2?-triazole-5-yl) (5-phenyI-l, 3,4-oxadiazole-2-yl) Sul fides

FENG Xiao-Ming1, CHEN Rong1, ZHANG Zi-Yi2   

  1. 1. Department of Chemistry, Southwest Normal University, Chongqing, 630715;
    2. Department of Chemistry, Lanzhou University, Lanzhou
  • Received:1992-11-27 Revised:1993-05-03 Online:1993-10-24 Published:1993-10-24

PDF (PC)

被引次数

5

摘要： 通过3-苄基-4-芳酰基-1,2,4-三唑-5-巯基负离子在2-甲磺酰基-5-苯基-1,3,4-噁二唑环2-位上的亲核取代反应,制得13个新的(3-苄基-4-芳酰基-1,2,4-三唑-5-基)(5-苯基-1,3,4-噁二唑-2-基)硫醚衍生物.经元素分析、IR、1HNMR和MS裂解碎片分析确认结构.初步观察了它们在0.01％浓度时对大肠杆菌繁殖的抑制作用.

关键词: 1, 2, 4-三唑, 1, 3, 4-噁二唑, 亲核取代, 抗菌活性

Abstract: Thirteen new (3-benzyl-4-aroyl-1, 2, 4-triazole-5-yl) (5-phenyl-1, 3, 4-oxadiazole-2-yl) sulfides (2) have been synthesized from the nucleophilic displacement of 3-benzyl-4-aroyl-1, 2,4-triazole-5-hydrosulfuryl anion on the 2-position of 2-methylsulfonyl-5-phenyl-1,3, 4-oxadia-zole.The structures of all compounds 2 were confirmed by elemental analysis, IR, 1H NMRand MS.Compounds 2 were screened for their antifungal activity against E.Coli at 0.01%.The results show that some compounds 2 have stronger inhibiting effects.

Key words: 1,2,4-Triazole,1,3,4-Oxadiazole, Nucleophilic displacement, Antifungal activity

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