高等学校化学学报

高等学校化学学报 ›› 1993, Vol. 14 ›› Issue (10): 1374.

• 研究简报 • 上一篇    下一篇

碳纤维微电极伏安法测定动物脑内5-羟吲哚乙酸、尿酸和高香草酸

彭图治1, 王国顺1, 李惠萍1, 刘国卿2, 曹于平2   

  1. 1. 杭州大学化学系, 杭州 310028;
    2. 中国药科大学药学系
  • 收稿日期:1992-10-12 修回日期:1993-04-15 出版日期:1993-10-24 发布日期:1993-10-24
  • 通讯作者: 彭图治, 男, 46岁, 副教授.
  • 作者简介:彭图治, 男, 46岁, 副教授.
  • 基金资助:

    国家自然科学基金;浙江省自然科学基金

Voltammetric Determination of 5-Hydroxyindol-acetic Acid, Uric Acid and Homovanillic Acid in Animal Brain with Carbon Fiber Electrodes

PENG Tu-Zhi1, WANG Guo-Shun1, LI Hui-Ping1, LIU Guo-Qing2, CAO Yu-Ping2   

  1. 1. Department of Chemistry, Ilangzhou University, Ilangzhou, 310028;
    2. Department of Pharmacology, China Pharmaceutical University, Nanjing
  • Received:1992-10-12 Revised:1993-04-15 Online:1993-10-24 Published:1993-10-24

PDF (PC)

被引次数

8

关键词: 碳纤维电极, 半微分伏安法, 神经递质, 尿酸

Abstract: An simple electrochemical pretreatment has been used to active carbon fiber electrodes for in vivo determination.In rat brain, there were four well-defined semi-differential voltammet-ric peaks.The peak at 0.36 Vwas combined by oxidative current of 5-HIAAand UA, 5-HIAAwas about 80% and UAabout 20%.The oxidation of HVAformed the peak at 0.54 V.The concentrations in brain extracellular fluid were determined, 5-HIAA, 3×10-6 mol/L; UA, 9×10-5 mol/Land HVA 8×10-6 mol/L.

Key words: Carbon fiber electrode, Semi-differential voltammetry, Neurotransmitter, Uric acid

TrendMD: