高等学校化学学报

高等学校化学学报 ›› 1993, Vol. 14 ›› Issue (1): 65.

• 研究简报 • 上一篇    下一篇

2-芳酰氨基-5-苄基-1,3,4-噻二唑的合成及其与苯甲醛反应的研究

冯小明1, 陈荣1, 黄劲松1, 张自义2   

  1. 1. 西南师范大学化学系, 重庆 630715;
    2. 兰州大学化学系
  • 收稿日期:1992-03-06 修回日期:1992-06-20 出版日期:1993-01-24 发布日期:1993-01-24
  • 通讯作者: 冯小明

Synthesis of 2-Aroylamido-5-benzyl-1,3,4-thiadiazoles and Studies on Their Reactions with Benzaldehyde

FENG Xiao-Ming1, CHEN Rong1, HUANG Jin-Song1, ZHANG Zi-Yi2   

  1. 1. Department of Chemistry, Southiwest Normal Uniivrsity, Chongqing, 630715;
    2. Department of Chemistry, Lanzhou University
  • Received:1992-03-06 Revised:1992-06-20 Online:1993-01-24 Published:1993-01-24

PDF (PC)

被引次数

5

关键词: 酰氮基硫脲, 1, 3, 4-噻二唑, 亲核加成

Abstract: In this paper, thirteen new 2-aroylamido-5-benzyl-1, 3, 4-thiadiazoles 2a-m were synthesized by cyclization 1-phenylacetyl-4-aroylthiosemicarbazides la-m in ice acetic acid.Thirteen new 2-aroylamido-5-(1'-phenyl-2'-hydroxyphenylethyl)-l,3,4-thiadiazoles 3a-m were obtained by nucle-ophilic addition of benzyl carbanion of 2a-m with benzaldehyde in EtONa-EtOHsolution.The structures of compounds 2a-m and those of 3a-m were confirmed by elementary analysis, IR, 1H NMR, and MS.

Key words: Acylthiosemicarbazide, 1, 3, 4-Thiadiazoles, Nucleophilic addition

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