高等学校化学学报

高等学校化学学报 ›› 1992, Vol. 13 ›› Issue (8): 1080.

• 论文 • 上一篇    下一篇

2,4-二氨基-5-取代苄基嘧啶类质谱研究

庞吉海1, 彭嘉柔1, 粱伟升1, 吴志儒1, 张海鹰1, 方肇霞2, 李仁利2   

  1. 1. 北京医科大学分析计算中心, 北京, 100083;
    2. 北京医科大学药学院
  • 收稿日期:1991-03-02 修回日期:1992-04-26 出版日期:1992-08-24 发布日期:1992-08-24
  • 通讯作者: 庞吉海

Studies on EIMS and MIKES of the Derivatives of 2,4-Diamino-5-(Substituted) Benzyl-Pyrimidine

PANG Ji-Hai1, PENG Jia-Ro1, LIANG Wei-Sheng1, WU Zhi-Ru1, ZHANG Hai-Ying1, FANG Zhao-Xia2, LI Ren-Li2   

  1. 1. Center of Analysis and Computation, Beijing Medical University, Beijing, 100083;
    2. School of Pharmacy, Beijing Medical University, Beijing
  • Received:1991-03-02 Revised:1992-04-26 Online:1992-08-24 Published:1992-08-24

PDF (PC)

摘要： 报道了8个2,4-二氨基-5-取代苄基嘧啶衍生物的电子轰击质谱及碰撞活化解离和质量分析离子动能谱.该谱提供了化合物醚键及2,4-二氨基-5-取代苄基嘧啶环的主要碎裂途径,总结了一些裂解规律,将有助于这类化合物的结构推断。

关键词: 2, 4-二氨基-5-取代苄基嘧啶, 电子轰击质谱, 碰撞活化解离和质量分析离子动能谱

Abstract: The present paper covers the electron ionization mass spectra (EIMS) and collisional activation dissociation (CAD),mass-analyzied ion kinetic energy spectra (MIKES) of eight 2,4-diamino-5-(substituted) benzyl-pyrimidine derivatives.Accurate molecular weight of the compounds were determined by means of high resolution experiments.The rules of the cleavage of ether bonds and 2,4-diamino-5-(substituted) benzyl-pyrimidine ring in the compounds were proved by the CAD MIKES technique.The fragmentations of sample 4 were studied in detail.

Key words: 2,4-Diamino-5-(substituted)benzyl-pyrimidine, EIMS, CAD and MIKES

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