高等学校化学学报

高等学校化学学报 ›› 1992, Vol. 13 ›› Issue (7): 947.

• 论文 • 上一篇    下一篇

大环二萜类化合物的研究(Ⅳ)——Isosarcophytol—A前体化合物的合成

李裕林, 李卫东, 李瀛   

  1. 兰州大学有机化学研究所, 应用有机化学国家重点实验室, 兰州, 730000
  • 收稿日期:1991-03-07 修回日期:1992-05-11 出版日期:1992-07-24 发布日期:1992-07-24
  • 通讯作者: 李裕林
  • 基金资助:

    国家自然科学基金;国家教育委员会博士点基金资助课题.

Studies on Macrocyclic Diterpenoids(Ⅳ)——Synthesis of Isosarcophytol-A Precursor

LI Yu-lin, LI Wei-dong, LI Ying   

  1. Institute of Organic Chemistry, State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, 730000
  • Received:1991-03-07 Revised:1992-05-11 Online:1992-07-24 Published:1992-07-24

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关键词: 大环二萜, Isosarcophytol&mdash, A, (E, E, E)-3, 7, 11, 15-四甲基-12, 叔丁基二苯基硅醚基-14-酮-2, 6, 10-十六碳三烯-1-醛, 羟醛缩合

Abstract: 3,7,11,15-Tetramethyl-12-tert-butyldiphenylsilyl ether-14-oxo-2E,6E,10E-hex-adecatrienal(11), the precursor of isosarcophytol-A, has been synthesized via six steps with (E, E)-farnesol (4) as starting material.The key steps in the synthesis are regionselective oxidation of farnesyl acetate (5) and aldol condensation of aldehyde 8 with methyl isopropyl ketone.

Key words: Macrocyclic diterpenoid, Isosarcophytol-A,3,7,11,15-Tetramethyl-12-tert-butyldiphenylsilyl ether-14-oxo-2E,6E,10E-hexadecatrienal, Aldol condensation

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