高等学校化学学报

高等学校化学学报 ›› 1992, Vol. 13 ›› Issue (7): 936.

• 论文 • 上一篇    下一篇

酰氨基硫脲及其相关杂环衍生物的研究(ⅩⅩⅤ)——1-(2,4-二氯苯氧乙酰基)-4-芳酰基氨基硫脲的合成及其碱催化环化行为的研究

张自义, 林海霞   

  1. 兰州大学化学系, 兰州, 730000
  • 收稿日期:1991-06-14 出版日期:1992-07-24 发布日期:1992-07-24
  • 通讯作者: 张自义

Studies on the Acylaminothiosemicarbazides and the Related Heterocyclic Derivatives(ⅩⅩⅤ)——Synthesis of-1-(2,4-dichIorophenoxylacetyl)-4-aroylthiosemicarbazides and Studies on Its cyclization Behavior Under Basic Catalysis

ZHANG Zi-yi, LIN Hai-xia   

  1. Department of Chemistry, Lanzhou University, Lanzhou, 730000
  • Received:1991-06-14 Online:1992-07-24 Published:1992-07-24

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摘要： 本文合成了20种新的1-(2,4-二氯苯氧乙酰基)-4-芳酰基氨基硫脲3,研究了化合物3在碱催化条件下的环化行为。结果表明离析物为3-芳基-4H-1,2,4-三唑-5-硫酮4.文中还讨论了化合物3的环化机制.经元素分析、IR及MS等方法确认了3及4的结构。

关键词: 酰氨基硫脲, 杂环, 1, 2, 4-三唑-5-硫酮

Abstract: In this paper, a series of new l-(2, 4-dichlorophenoxyacetyl)-4-aroylth-iosemicarbazides 3 were synthesized by the addition reaction of 2,4-dichlorophenoxyacetic acid hydrizide with aroyl isothiocyanate and the behavior of cyclization of compounds 3 in the presence of 2 mol/L KOHwere studied.The result shows that the reaction of compounds 3 in an alkaline medium gave 3-aryl-4H-l,2,4-triazoline-5-thione 4.The mechanism for the formation of compounds 4 was discussed.The structures of compounds prepared were characterized by elementary analysis, IRand MS.

Key words: Acylaminothiosemicarbazide, Heterocyclic, 1,2,4-triazoline-5-thione

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