高等学校化学学报

高等学校化学学报 ›› 1992, Vol. 13 ›› Issue (2): 187.

• 论文 • 上一篇    下一篇

双(1-乙酰基-4-取代苯甲酰基氨基硫脲)及其衍生物的合成

冯小明1, 陈荣1, 杨维东1, 张自义2   

  1. 1. 西南师范大学化学系, 重庆, 630715;
    2. 兰州大学化学系
  • 收稿日期:1991-01-03 出版日期:1992-02-24 发布日期:1992-02-24
  • 通讯作者: 冯小明

Synthesis of Bis(1-Acetyl-4-Aroylthiosemicarbazides) and Their Derivatives

FENG Xiao-ming1, CHEN Rong1, YANG Wei-dong1, ZHANG Zi-yi2   

  1. 1. Department of Chemistry, Southwest Teachers University, Chongqing, 630715;
    2. Department of Chemistry, Lanzhou University, Lanzhou
  • Received:1991-01-03 Online:1992-02-24 Published:1992-02-24

PDF (PC)

被引次数

24

摘要： 由丁二酰肼Ⅰ与取代苯甲酰基异硫氰酯在无水CaCl2处理过的乙腈溶剂中亲核加成,制得一系列未知的双(1-乙酰基-4-取代苯甲酰基氨基硫脲)衍生物Ⅱ,Ⅱ在碱性条件下环化为未知的双(3-亚甲基-4-取代苯甲酰基-1,2,4-三唑啉-5-硫酮)Ⅲ,所有化合物结构均经鉴定,部分化合物对枯草芽孢杆菌和大肠杆菌有抑制作用。

关键词: 双(1-乙酰基-4-取代苯甲酰基氨基硫脲), 1, 2, 4-三唑啉-5-硫酮, 生物活性

Abstract: A series of new bis(1-acetyl-4-aroylthiosemicarbazides) Ⅱ were synthesized by condensation of aroylisothiocyanates with succinylhydrazine Ⅰ in acetonitrileSome bis(3-methenyl-4-aroyl-l,2,4-triazoline-5-thiones) Ⅲ were obtained in good yields (42.7%～96.2%) through the cyclization of the compounds Ⅱ with 1 mol/L K2CO3 solutionThe structures of compounds Ⅱ and Ⅲ were characterized by elemental analysis, IR, 1H NMR and MS. Antibacterial activity tests of these compounds against BSubtills and EColi show that compounds Ⅱd-h, Ⅲd-h, are the most effective species.

Key words: Bis (1-Acetyl-4-aroylthiosemicarbazides), 1,2,4-Triazoline-5-thione, Antibacterial activity

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