高等学校化学学报

高等学校化学学报 ›› 1991, Vol. 12 ›› Issue (4): 441.

• 论文 • 上一篇    下一篇

金属-血清白蛋白的结构研究(Ⅴ)--钴离子与HSA和BSA的相互作用

周永洽, 刘宏, 车云霞, 申泮文   

  1. 南开大学化学系, 300071
  • 收稿日期:1989-07-29 出版日期:1991-04-24 发布日期:1991-04-24
  • 通讯作者: 周永洽

Structural Studies on Metal-Serum Albumin (Ⅴ)--Interactions Between Co(Ⅱ),Co(Ⅲ) Ions and HSA or BSA

Zhou Yong-qia, Liu Hong, Che Yun-xia, Shen Pan-wen   

  1. Department of Chemistry, Nankai University, Tianjin, 300071
  • Received:1989-07-29 Online:1991-04-24 Published:1991-04-24

PDF (PC)

被引次数

19

摘要： 血清白蛋白是血清中含量最丰富的蛋白质,是多种金属离子的输运蛋白。钴(Ⅱ)离子在金属蛋白研究中经常被用作光谱探针。但Co(Ⅱ)与血清白蛋白的相互作用却很少被研究。

关键词: 电荷转移光谱, 光学电负性, 血清白蛋白, 钴

Abstract: The interactions between Co(Ⅱ) ion and HSAor BSAwere studied by means of charge transfer spectra. Both Co(Ⅱ) and Co(Ⅲ) have been found at the binding sites of albumin. The coordination environment of Co(Ⅱ) and Co(Ⅲ) are likely to be identical, which are octahedral type involving α-amino and carboxyl. So these ions are likely to locate at the N-terminal of albumin.

Key words: Charge transfer spectra, Optical electronegativity, Serum albumin, Cobalt

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