高等学校化学学报 ›› 1990, Vol. 11 ›› Issue (5): 476-480.

• 研究论文 • 上一篇    下一篇

利用磷试剂制备2-[4,5-二氢化-4-甲基-4-异丙基-5-氧代-1H-咪唑啉-2-基]-苯甲酸的衍生物

陈茹玉, 刘立建   

  1. 南开大学元素有机化学研究所
  • 收稿日期:1989-02-04 出版日期:1990-05-24 发布日期:1990-05-24
  • 通讯作者: 陈茹玉
  • 基金资助:

    国家博士后科学基金

Application of Several Phosphorous Agents to the Preparation of Some Derivatives of 2-(4,5-Dihydro-4-Isopropyl-4-Methyl-5-Oxo-1H-Imidazoline-2-yl)-Benzoic Acid

Chen Ruyu, Liu Lijian   

  1. The Institute of Elemento-Organic Chemistry, Nankai University, Tianjin
  • Received:1989-02-04 Online:1990-05-24 Published:1990-05-24

摘要: 本文报告了利用磷试剂制备2-氧代-3-甲基-3-异丙基-3H-咪唑并[2,1-a]-1-氧代-异吲哚及其异构体3-氧代-2-甲基-2-异丙基-2H-咪唑并[2,1-a]-1-氧代-异吲哚和2-[4,5-二氢化-4-甲基-4-异丙基-5-氧代-1H-咪唑啉-2-基]-N,N-二烷基-苯甲酰胺的新方法。本文方法具有反应条件温和、反应时间较短和收率较高等特点。

关键词: 磷试剂, 环化, 酰胺化, 互变异构

Abstract: This paper is about the application of several phosphorous agents to the synthesis of somederivatives of 2-(4,5-dihydro-4-isopropyl-4-methyl-5-oxo-1H-imidazoline-2-yl)-benzoic acid( I ) .Ireacted with O,O-diethyl phosphorochloridothioic ester to give out a mixture of 1 : 1 of 2-oxo-3-isopropyl-3-methyl-3H-imidazoine[2,1-a]-1-oxo-isoindole and its isomer. But when I was stirredwith hexaalkyl phosphorous triamide in THF N,N-dialkyl amide of I was isolated.

Key words: Phosphorous agent, Cyclization, Amidation, Tautomerism