高等学校化学学报

高等学校化学学报 ›› 1989, Vol. 10 ›› Issue (12): 1254.

• 研究简报 • 上一篇    下一篇

1-(3-芳亚甲基氨基)丙基-2,8,9-三氧杂-5-氮杂-1-硅杂双环[3,3,3]十一烷金属络合物的合成及其抗肿瘤活性研究

丁齐柱, 罗宣干, 卓仁禧   

  1. 武汉大学化学系
  • 收稿日期:1988-05-14 出版日期:1989-12-24 发布日期:1989-12-24
  • 通讯作者: 卓仁禧

Studies on the Synthesis and Antitumor Activity of 3-(Arylmethyleneamino)propylsilatrane-Metal Complexes

Ding Qizhu, Luo Xuangan, Zhuo Renxi   

  1. Department of Chemistry, Wuhan University, Wuhan
  • Received:1988-05-14 Online:1989-12-24 Published:1989-12-24

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关键词: 抗肿瘤活性, Schiff碱, 金属络合物, 2, 8, 9-三氧杂-5-氮杂-1-硅杂双环[3, 3, 3]十一烷

Abstract: Ten 3-(arylmethyleneamino)propylsilatrane-metal complexes were synthesized by the reaction of metal salt with 3- (2-hydroxybenzylideneamino) propylsilatrane or 3-(2, 4-dihydroxyben-zylideneamino)propylsilatrane in methanol.The structure of these new complexes were identified by 1H NMR, IRand elemental analysis.Animal screening data show that the inhibition ratio of bis-[N-(3-silatranylpropyl)-2-hydroxybenzylideneaminato] copper(Ⅱ) against Erlich ascites cancer in mice is 42.7%.

Key words: Antitumor activity, Schiff base, Metal complex, 2,8,9-Trioxa-5-aza-l-sila-bicyclo[3,3,3]-undecane

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