高等学校化学学报

高等学校化学学报 ›› 1989, Vol. 10 ›› Issue (10): 1007.

• 研究论文 • 上一篇    下一篇

1-(3-氨基丙基)-2,8,9-三氧杂-5-氮杂-1-硅杂双环[3,3,3]十一烷衍生物的合成及其抗肿瘤活性研究

丁齐柱, 罗宣干, 卓仁禧   

  1. 武汉大学化学系
  • 收稿日期:1988-05-14 出版日期:1989-10-24 发布日期:1989-10-24
  • 通讯作者: 卓仁禧

Studies on the Synthesis and Antitumor Activity of 3-Aminopropylsilatrane Derivatives

Ding Qizhu, Luo Xuangan, Zhuo Renxi   

  1. Department of chemistry, Wuhan University, Wuhan
  • Received:1988-05-14 Online:1989-10-24 Published:1989-10-24

PDF (PC)

被引次数

7

摘要： 通过1-(3-氨基丙基)-2,8,9-三氧杂-5-氮杂-1-硅杂双环[3,3,3]十一烷与酸反应或1-(3-氯丙基)-2,8,9-三氧杂-5-氮杂-1-硅杂双环[3,3,3]十一烷与胺反应,合成了14种1-(3-氨基丙基)-2,8,9-三氧杂-5-氮杂-1-硅杂双环[3,3,3]十一烷衍生物.体外细胞培养试验结果表明,某些1-(3-氨基丙基)-2,8,9-三氧杂-5-氮杂-1-硅杂双环[3,3,3]十一烷衍生物对艾氏腹水癌细胞具有较好的杀伤活性.

关键词: 抗肿瘤活性, 2, 8, 9-三氧杂-5-氮杂-1-硅杂双环[3, 3, 3]十一烷, 1-(3-氨基丙基)-2, 8, 9-三氧杂-5-氮杂-1-硅杂双环[3, 3, 3]十一烷, 1-(3-氯丙基)-2, 8, 9-三氧杂-5-氮杂-1-硅杂双环[3, 3, 3]十一烷

Abstract: Fourteen new derivatives of 3-aminopropylsilatrane were synthesized by the reaction of 3-aminopropylsilatrane with acids or 3-chloropropylsilatrane with amines.The structures of these compounds were identified with 1H NMR, IRand elemental analysis.The results of in vitro cell culture testing showed that some of the silatrane derivatives exhibit good antitumor activity.

Key words: Antitumor activity, 2,8,9-Trioxa-5-aza-1-silabicyclo[3,3,3]undecane, 3-Aminopropyl-2,9-trioxa-5-aza-1-silabicyclo[3,3,3]undecane, 3-Chloropropyl-2,9-trioxa-5-aza-1-silabicy-clo[3,3,3]undecane

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