高等学校化学学报

高等学校化学学报 ›› 1988, Vol. 9 ›› Issue (9): 969.

• 论文 • 上一篇    下一篇

脱氢醋酸与氨的反应

陈伟兴, 冯骏材, 傅和亮, 沙坚, 张林   

  1. 南京大学化学系
  • 收稿日期:1987-03-31 出版日期:1988-09-24 发布日期:1988-09-24
  • 通讯作者: 冯骏材

Study on the Reaction of Dehydroacetic acid with Ammonia

Chen Weixing, Feng Juncai, Fu Heliang, Sha Jian, Zhang Lin   

  1. Department of Chemistry, Nanjing University, Nanjing
  • Received:1987-03-31 Online:1988-09-24 Published:1988-09-24

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被引次数

3

摘要： 脱氢醋酸(1)与氨反应生成2,6-二甲基-4-羟基吡啶(2)[1]。IguChi等[2]曾用纸层析法定性地研究了这反应的过程。为进一步了解(1)与氨反应的历程及影响反应的因素,我们用HPLC研究了在不同反应条件下得到的中间体和产物,研究了相互转变关系,并进行了分离和鉴定。初步提出了该反应的可能历程。

关键词: 脱氢醋酸, 2, 6-二甲基-4-羟基吡啶

Abstract: In this work, the reaction of dehydroacetic acid (1) with aqueous ammoniahas been further studied by means of HPLC. In this reaction lutidone (2), lutidonecarboxylic acid (4) and 2,6-dimethyl-4-aminopyridine (6) have been separated or prepared.DHA-imide (3) (3-iminoethyl-4-hydroxy-6-methyl-2-pyrone) is the intermediate which gives various compounds under different conditions. The mechanism of this reaction is discussed.The structures of compounds have beeen characterized by IR, 1HNMR and MSspectra.

Key words: Dehydroacetic acid, 2,6-dimethyl-4-hydroxypyridine

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